Gut microbiota and cardiovascular disease: opportunities and challenges

N Kazemian, M Mahmoudi, F Halperin, JC Wu… - Microbiome, 2020 - Springer
Coronary artery disease (CAD) is the most common health problem worldwide and remains
the leading cause of morbidity and mortality. Over the past decade, it has become clear that …

Macrophage death and defective inflammation resolution in atherosclerosis

I Tabas - Nature Reviews Immunology, 2010 - nature.com
A key event in atherosclerosis is a maladaptive inflammatory response to subendothelial
lipoproteins. A crucial aspect of this response is a failure to resolve inflammation, which …

Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy

JE McLaren, DR Michael, TG Ashlin, DP Ramji - Progress in lipid research, 2011 - Elsevier
Cardiovascular disease is the biggest killer globally and the principal contributing factor to
the pathology is atherosclerosis; a chronic, inflammatory disorder characterized by lipid and …

Butyrate impairs atherogenesis by reducing plaque inflammation and vulnerability and decreasing NFκB activation

EC Aguilar, AJ Leonel, LG Teixeira, AR Silva… - Nutrition, Metabolism …, 2014 - Elsevier
Background & aims Butyrate is a four-carbon fatty acid that presents anti-inflammatory, anti-
oxidative and apoptotic properties in colon and several cell lines. Because atherosclerosis …

CD36 and macrophages in atherosclerosis

S Collot-Teixeira, J Martin… - Cardiovascular …, 2007 - academic.oup.com
CD36 is a multi-ligand scavenger receptor present on the surface of a number of cells such
as platelets, monocytes/macrophages, endothelial and smooth muscle cells. Monocyte …

Crosstalk between cholesterol metabolism and psoriatic inflammation

L Luo, Y Guo, L Chen, J Zhu, C Li - Frontiers in Immunology, 2023 - frontiersin.org
Psoriasis is a chronic autoinflammatory skin disease associated with multiple comorbidities,
with a prevalence ranging from 2 to 3% in the general population. Decades of preclinical …

Differentiation factors and cytokines in the atherosclerotic plaque micro-environment as a trigger for macrophage polarisation

IMJ Wolfs, MMPC Donners… - Thrombosis and …, 2011 - thieme-connect.com
The phenotype of macrophages in atherosclerotic lesions can vary dramatically, from a large
lipid laden foam cell to a small inflammatory cell. Classically, the concept of macrophage …

Interleukin-10 protects against atherosclerosis by modulating multiple atherogenic macrophage function

X Han, WA Boisvert - Thrombosis and haemostasis, 2015 - thieme-connect.com
Atherosclerosis is primarily a disorder of lipid metabolism, but there is also a prominent
chronic inflammatory component that drives the atherosclerotic lesion progression in the …

CD36: implications in cardiovascular disease

M Febbraio, RL Silverstein - The international journal of biochemistry & cell …, 2007 - Elsevier
CD36 is a broadly expressed membrane glycoprotein that acts as a facilitator of fatty acid
uptake, a signaling molecule, and a receptor for a wide range of ligands, including apoptotic …

Roles of ATP binding cassette transporters A1 and G1, scavenger receptor BI and membrane lipid domains in cholesterol export from macrophages

W Jessup, IC Gelissen, K Gaus… - Current opinion in …, 2006 - journals.lww.com
Roles of ATP binding cassette transporters A1 and G1, scaven... : Current Opinion in Lipidology
Roles of ATP binding cassette transporters A1 and G1, scavenger receptor BI and membrane …