The promising potential of reverse vaccinology-based next-generation vaccine development over conventional vaccines against antibiotic-resistant bacteria

K Khalid, CL Poh - Vaccines, 2023 - mdpi.com
The clinical use of antibiotics has led to the emergence of multidrug-resistant (MDR)
bacteria, leading to the current antibiotic resistance crisis. To address this issue, next …

Typhoid fever control in the 21st century: where are we now?

ME Carey, NS McCann, MM Gibani - Current opinion in infectious …, 2022 - journals.lww.com
Typhoid fever control in the 21st century: where are we now? : Current Opinion in Infectious
Diseases Typhoid fever control in the 21st century: where are we now? : Current Opinion in …

Salmonella Combination Vaccines: Moving Beyond Typhoid

CA MacLennan, J Stanaway, S Grow… - Open Forum …, 2023 - academic.oup.com
There is now a robust pipeline of licensed and World Health Organization (WHO)–
prequalified typhoid conjugate vaccines with a steady progression of national introductions …

Taking on typhoid: eliminating typhoid fever as a global health problem

J Chen, JE Long, K Vannice… - Open Forum …, 2023 - academic.oup.com
Typhoid fever is a significant global health problem that impacts people living in areas
without access to clean water and sanitation. However, collaborative international …

A Bivalent MAPS Vaccine Induces Protective Antibody Responses against Salmonella Typhi and Paratyphi A

F Zhang, EM Boerth, J Gong, N Ma, K Lucas, O Ledue… - Vaccines, 2022 - mdpi.com
Infections by Salmonella Typhi and Paratyphi A strain are still a major cause of morbidity
and mortality in developing countries. Generation of antibodies against the Vi capsular …

A randomized, observer-blind, controlled phase III clinical trial assessing safety and immunological non-inferiority of VI-diphtheria Toxoid versus VI-tetanus Toxoid …

S Chaudhary, GS Shah, NK Bhatta… - Human Vaccines & …, 2023 - Taylor & Francis
Typhoid remains one of the major serious health concerns for children in developing
countries. With extremely drug-resistant cases emerging, preventative measures like …

Safety and immunogenicity of Vi-diphtheria toxoid typhoid conjugate vaccine among children below 2 years: a systematic review and meta-analysis

A Mohamed Taha, K Abouelmagd… - Frontiers in …, 2024 - frontiersin.org
Background The Vi-diphtheria toxoid typhoid conjugate vaccine (Vi-DT) has shown
promising results in preventing typhoid fever in children under 2 years of age. However, a …

Salmonella Typhi whole genome sequencing in Rwanda shows a diverse historical population with recent introduction of haplotype H58

JP Rutanga, T de Block, WL Cuypers… - PLoS neglected …, 2023 - journals.plos.org
Salmonella enterica serovar Typhi (S. Typhi) is the cause of typhoid fever, presenting high
rates of morbidity and mortality in low-and middle-income countries. The H58 haplotype …

Safety and immunogenicity of inactivated and recombinant protein SARS-coV-2 vaccines in patients with thyroid cancer

Y Han, J Yang, D He, Y Feng, X Liu, Y Min… - Frontiers in …, 2022 - frontiersin.org
Background This study aimed at assessing the safety and immunogenicity of SARS-CoV-2
vaccines in patients with thyroid cancer. Methods This observational study included thyroid …

Safety and immunogenicity of conjugate vaccine for typhoid (Vi-DT): Finding from an observer-blind, active-controlled, randomized, non-inferiority, phase III clinical …

D Tamrakar, P Poudel, P Thapa, S Singh… - Human Vaccines & …, 2024 - Taylor & Francis
Typhoid fever is a significant public health concern with most of the sufferers between 15
and 25 y of age in Nepal. We undertook this study to demonstrate Vi polysaccharide …