Poorly water-soluble drugs continue to be a problematic, yet important class of
pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in …

Although oral drug delivery is the preferred administration route and has been used for
centuries, modern drug discovery and development pipelines challenge conventional …

Liquid-liquid phase separation (LLPS) occurs following amorphous solid dispersion (ASD)
dissolution when the drug concentration exceeds the “amorphous solubility”, and is …

The generation of a colloidal drug-rich phase by dissolving an amorphous solid dispersion
(ASD) is thought to have a positive impact on oral absorption and bioavailability. Thus …

Many pharmaceutical drugs in the marketplace and discovery pipeline suffer from poor
aqueous solubility, thereby limiting their effectiveness for oral delivery. The use of an …

Does the performance of an amorphous solid dispersion rely on having 100% amorphous
content? What specifications are appropriate for crystalline content within an amorphous …

Amorphous solid dispersion (ASD) is a promising strategy to enhance solubility and
bioavailability of poorly water-soluble drugs. Due to higher free energy of ASD …

Purpose To understand the role of different surfactants, incorporated into amorphous solid
dispersions (ASDs) of ritonavir and copovidone, in terms of their impact on release, phase …

Amorphous solid dispersions (ASDs) have been proven to increase the bioavailability of
poorly soluble drugs. It is desirable that the ASD provide a rapid dissolution rate and a …

Supersaturating formulations are increasingly being used to improve the absorption of orally
administered poorly water-soluble drugs. To better predict outcomes in vivo, we must be …