Berberine for gastric cancer prevention and treatment: Multi-step actions on the Correa's cascade underlie its therapeutic effects

Q Liu, J Tang, S Chen, S Hu, C Shen, J Xiang… - Pharmacological …, 2022 - Elsevier
Gastric carcinoma (GC) is a complex multifactorial disease occurring as sequential events
commonly referred to as the Correa's cascade, a stepwise progression from non-active or …

Immunology of bile acids regulated receptors

S Fiorucci, S Marchianò, G Urbani, C Di Giorgio… - Progress in Lipid …, 2024 - Elsevier
Bile acids are steroids generated at the interface of host and intestinal microbiota. While
primary bile acids are generated in the liver from cholesterol metabolism, secondary bile …

[HTML][HTML] Recent findings regarding the synergistic effects of emodin and its analogs with other bioactive compounds: insights into new mechanisms

Y Hu, L Yang, Y Lai - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Context Emodin is a natural bioactive ingredient mainly extracted from traditional Chinese
herbs. Increasing lines of evidence suggest that emodin and its analogs exert notable …

Structure-based profiling of potential phytomolecules with AKT1 a key cancer drug target

Z Mirza, S Karim - Molecules, 2023 - mdpi.com
Identifying cancer biomarkers is imperative, as upregulated genes offer a better
microenvironment for the tumor; hence, targeted inhibition is preferred. The theme of our …

Molecular classifications in gastric cancer: A call for interdisciplinary collaboration

C Díaz del Arco, MJ Fernández Aceñero… - International Journal of …, 2024 - mdpi.com
Gastric cancer (GC) is a heterogeneous disease, often diagnosed at advanced stages, with
a 5-year survival rate of approximately 20%. Despite notable technological advancements in …

Phenotypic spectrum of FGF10-related disorders: a systematic review

K Bzdega, JA Karolak - PeerJ, 2022 - peerj.com
FGF10, as an FGFR2b-specific ligand, plays a crucial role during cell proliferation, multi-
organ development, and tissue injury repair. The developmental importance of FGF10 has …

Next-generation sequencing analysis of gastric cancer identifies the leukemia inhibitory factor receptor as a driving factor in gastric cancer progression and as a …

C Di Giorgio, S Marchianò, E Marino, M Biagioli… - Frontiers in …, 2022 - frontiersin.org
Gastric cancer (GC) is the third cause of cancer-related mortality worldwide. Nevertheless,
because GC screening programs are not cost-effective, most patients receive diagnosis in …

Identification of circRNA–miRNA–Immune-Related mRNA Regulatory Network in Gastric Cancer

Z Wu, P Liu, G Zhang - Frontiers in Oncology, 2022 - frontiersin.org
The pathogenesis of gastric cancer (GC) is still not fully understood. We aimed to find the
potential regulatory network for ceRNA (circRNA–miRNA–immune-related mRNA) to …

Transcriptome Analysis of the Inhibitory Effects of 20 (S)-Protopanaxadiol on NCI-H1299 Non-Small Cell Lung Cancer Cells

Z Cong, X Zhang, Z Lv, J Jiang, L Wang, J Li, J Wang… - Molecules, 2023 - mdpi.com
Lung cancer seriously threatens human health. To explore the molecular mechanism of 20
(S)-Protopanaxadiol (PPD) on human non-small cell lung cancer cells, we investigated the …

Functional proteomic profiling analysis in four major types of gastrointestinal cancers

Y Wang, X Gao, J Wang - Biomolecules, 2023 - mdpi.com
Gastrointestinal (GI) cancer accounts for one in four cancer cases and one in three cancer-
related deaths globally. A deeper understanding of cancer development mechanisms can …