Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase
Little is known about the impact of pretreatment drug resistance (PDR) on the efficacy of
second generation integrase inhibitors. We sequenced pretreatment plasma specimens …
second generation integrase inhibitors. We sequenced pretreatment plasma specimens …
Bictegravir in a fixed-dose tablet with emtricitabine and tenofovir alafenamide for the treatment of HIV infection: pharmacology and clinical implications
HT Pham, T Mesplède - Expert opinion on pharmacotherapy, 2019 - Taylor & Francis
Introduction: Current antiretroviral therapy is more effective and simpler than in previous
times due to the development of new drugs with improved pharmacokinetic and …
times due to the development of new drugs with improved pharmacokinetic and …
Pre-treatment integrase inhibitor resistance and natural polymorphisms among HIV-1 subtype C infected patients in Ethiopia
DA Arimide, ZI Szojka, K Zealiyas, A Gebreegziabxier… - Viruses, 2022 - mdpi.com
Dolutegravir-based antiretroviral therapy (ART) has been scaled up in many developing
countries, including Ethiopia. However, subtype-dependent polymorphic differences might …
countries, including Ethiopia. However, subtype-dependent polymorphic differences might …
Baseline integrase drug resistance mutations and conserved regions across HIV-1 clades in Cameroon: implications for transition to dolutegravir in resource-limited …
Background Transition to dolutegravir-based regimens in resource-limited settings (RLS)
requires prior understanding of HIV-1 integrase variants and conserved regions. Therefore …
requires prior understanding of HIV-1 integrase variants and conserved regions. Therefore …
Molecular dynamic simulations to investigate the structural impact of known drug resistance mutations on HIV-1C Integrase-Dolutegravir binding
Resistance associated mutations (RAMs) threaten the long-term success of combination
antiretroviral therapy (cART) outcomes for HIV-1 treatment. HIV-1 Integrase (IN) strand …
antiretroviral therapy (cART) outcomes for HIV-1 treatment. HIV-1 Integrase (IN) strand …
Drug resistance and optimizing dolutegravir regimens for adolescents and young adults failing antiretroviral therapy
Objectives: The integrase strand inhibitor dolutegravir (DTG) combined with tenofovir and
lamivudine (TLD) is a single tablet regimen recommended for 1st, 2nd and 3rd-line public …
lamivudine (TLD) is a single tablet regimen recommended for 1st, 2nd and 3rd-line public …
Structural implications of genotypic variations in HIV-1 integrase from diverse subtypes
Human immunodeficiency virus type 1 (HIV-1) integrase (IN) integrates viral DNA into the
host genome using its 3′-end processing and strand-transfer activities. Due to the …
host genome using its 3′-end processing and strand-transfer activities. Due to the …
Primary resistance against integrase strand transfer inhibitors in integrase strand transfer inhibitor-naive patients failing first-and second-line ART in Tanzania
S Henerico, E Lyimo, AN Makubi… - Journal of …, 2022 - academic.oup.com
Abstract Introduction Sub-Saharan African countries are introducing integrase strand
transfer inhibitors (INSTIs) in their ART programmes as the preferred first-line regimen, and …
transfer inhibitors (INSTIs) in their ART programmes as the preferred first-line regimen, and …
Evaluation of virological response and resistance profile in HIV-1 infected patients starting a first-line integrase inhibitor-based regimen in clinical settings
Background Virological response and resistance profile were evaluated in drug-naïve
patients starting their first-line integrase inhibitors (INIs)-based regimen in a clinical setting …
patients starting their first-line integrase inhibitors (INIs)-based regimen in a clinical setting …
HIV-1 integrase diversity and resistance-associated mutations and polymorphisms among integrase strand transfer inhibitor-naive HIV-1 patients from Cameroon
SG Mikasi, JO Gichana, C Van der Walt… - AIDS research and …, 2020 - liebertpub.com
The World Health Organization (WHO) has put forth recommendations for the use of
integrase (IN) strand transfer inhibitors (INSTIs) to be part of the first-line combination …
integrase (IN) strand transfer inhibitors (INSTIs) to be part of the first-line combination …