Dopamine, noradrenaline and serotonin receptor densities in the striatum of hemiparkinsonian rats following botulinum neurotoxin-A injection
T Mann, K Zilles, H Dikow, A Hellfritsch, M Cremer… - Neuroscience, 2018 - Elsevier
Parkinson's disease (PD) is characterized by a degeneration of dopaminergic neurons in the
substantia nigra pars compacta (SNpc) that causes a dopamine (DA) deficit in the caudate …
substantia nigra pars compacta (SNpc) that causes a dopamine (DA) deficit in the caudate …
Olfactory Bulb D2/D3 Receptor Availability after Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson's Disease
T Alberts, V Antipova, C Holzmann, A Hawlitschka… - Toxins, 2022 - mdpi.com
Olfactory deficits occur as early non-motor symptoms of idiopathic Parkinson's disease (PD)
in humans. The first central relay of the olfactory pathway, the olfactory bulb (OB), depends …
in humans. The first central relay of the olfactory pathway, the olfactory bulb (OB), depends …
Intrastriatal injection of botulinum neurotoxin-A is not cytotoxic in rat brain–a histological and stereological analysis
J Mehlan, H Brosig, O Schmitt, E Mix, A Wree… - Brain research, 2016 - Elsevier
Parkinson׳ s disease (PD) is caused by progressive degeneration of dopaminergic neurons
in the substantia nigra pars compacta, resulting in a deficiency of dopamine in the striatum …
in the substantia nigra pars compacta, resulting in a deficiency of dopamine in the striatum …
Botulinum neurotoxin a injected ipsilaterally or contralaterally into the striatum in the rat 6-OHDA model of unilateral Parkinson's disease differently affects behavior
VA Antipova, C Holzmann, O Schmitt… - Frontiers in Behavioral …, 2017 - frontiersin.org
Parkinson's disease (PD) is one of the most frequent neurodegenerative disorders. The loss
of dopaminergic neurons in the substantia nigra leads to a disinhibition of cholinergic …
of dopaminergic neurons in the substantia nigra leads to a disinhibition of cholinergic …
Intrastriatal administration of botulinum neurotoxin A normalizes striatal D2R binding and reduces striatal D1R binding in male hemiparkinsonian rats
F Wedekind, A Oskamp, M Lang… - Journal of …, 2018 - Wiley Online Library
Cerebral administration of botulinum neurotoxin A (BoNT‐A) has been shown to improve
disease‐specific motor behavior in a rat model of Parkinson disease (PD). Since the …
disease‐specific motor behavior in a rat model of Parkinson disease (PD). Since the …
Experimental intrastriatal applications of botulinum neurotoxin-A: A review
A Hawlitschka, A Wree - International Journal of Molecular Sciences, 2018 - mdpi.com
Parkinson's disease (PD) is one of the most frequent neurodegenerative disorders. Its main
pathophysiological characteristic is the loss of dopaminergic neurons in the substantia nigra …
pathophysiological characteristic is the loss of dopaminergic neurons in the substantia nigra …
Acetylcholine neurotransmitter receptor densities in the striatum of hemiparkinsonian rats following Botulinum neurotoxin-A injection
T Mann, K Zilles, F Klawitter, M Cremer… - Frontiers in …, 2018 - frontiersin.org
Cholinergic neurotransmission has a pivotal function in the caudate-putamen, and is highly
associated with the pathophysiology of Parkinson's disease. Here, we investigated long …
associated with the pathophysiology of Parkinson's disease. Here, we investigated long …
Unilateral botulinum neurotoxin-A injection into the striatum of C57BL/6 mice leads to a different motor behavior compared with rats
V Antipova, A Wree, C Holzmann, T Mann… - Toxins, 2018 - mdpi.com
Different morphological changes in the caudate-putamen (CPu) of naïve rats and mice were
observed after intrastriatal botulinum neurotoxin-A (BoNT-A) injection. For this purpose we …
observed after intrastriatal botulinum neurotoxin-A (BoNT-A) injection. For this purpose we …
Intrastriatally injected botulinum neurotoxin-A differently effects cholinergic and dopaminergic fibers in C57BL/6 mice
A Hawlitschka, C Holzmann, S Witt, J Spiewok… - Brain Research, 2017 - Elsevier
Unilateral intrastriatal BoNT-A injection abolished apomorphine-induced rotational behavior
in a rat model of hemiparkinsonism (hemi-PD) up to 6 months. It was hypothesized that the …
in a rat model of hemiparkinsonism (hemi-PD) up to 6 months. It was hypothesized that the …
[18F]fallypride-PET/CT Analysis of the Dopamine D2/D3 Receptor in the Hemiparkinsonian Rat Brain Following Intrastriatal Botulinum Neurotoxin A Injection
T Mann, J Kurth, A Hawlitschka, J Stenzel, T Lindner… - Molecules, 2018 - mdpi.com
Intrastriatal injection of botulinum neurotoxin A (BoNT-A) results in improved motor behavior
of hemiparkinsonian (hemi-PD) rats, an animal model for Parkinson's disease. The caudate …
of hemiparkinsonian (hemi-PD) rats, an animal model for Parkinson's disease. The caudate …