[HTML][HTML] Repeated intrastriatal botulinum neurotoxin-A injection in hemiparkinsonian rats increased the beneficial effect on rotational behavior
A Hawlitschka, C Holzmann, A Wree, V Antipova - Toxins, 2018 - mdpi.com
Injection of botulinum neurotoxin-A (BoNT-A) into the striatum of hemiparkinsonian (hemi-
PD) rats reduced apomorphine-induced rotation behavior significantly, for at least 3 months …
PD) rats reduced apomorphine-induced rotation behavior significantly, for at least 3 months …
[HTML][HTML] Botulinum neurotoxin-a injected intrastriatally into hemiparkinsonian rats improves the initiation time for left and right forelimbs in both forehand and backhand …
V Antipova, C Holzmann, A Hawlitschka… - International Journal of …, 2019 - mdpi.com
Forelimb stepping is a widely used test for the assessment of forelimb akinesia in
hemiparkinsonian (hemi-PD) rats. The initiation time (IT) is considered the most sensitive …
hemiparkinsonian (hemi-PD) rats. The initiation time (IT) is considered the most sensitive …
Botulinum neurotoxin A subtype 2 reduces pathological behaviors more effectively than subtype 1 in a rat Parkinson's disease model
M Itakura, T Kohda, T Kubo, Y Semi, YT Azuma… - Biochemical and …, 2014 - Elsevier
Recent reports indicate that interruption of acetylcholine release by intrastriatal injection of
botulinum neurotoxin type A (BoNT/A) in a rat Parkinson's disease model reduces …
botulinum neurotoxin type A (BoNT/A) in a rat Parkinson's disease model reduces …
Repeated intrastriatal application of botulinum neurotoxin-A did not influence choline acetyltransferase-immunoreactive interneurons in hemiparkinsonian rat brain–A …
A Hawlitschka, C Berg, O Schmitt, C Holzmann, A Wree… - Brain Research, 2020 - Elsevier
In Parkinson's disease, dopamine depletion leads to hyperactivity of cholinergic
interneurons in the caudate-putamen (CPu). Botulinum neurotoxin-A (BoNT-A) inhibits the …
interneurons in the caudate-putamen (CPu). Botulinum neurotoxin-A (BoNT-A) inhibits the …
Unilateral whisker pad injection of botulinum toxin type a enhances spatial learning in mice
LH Ni, SX Cao, H Lian, XY Hu - NeuroReport, 2018 - journals.lww.com
The central cholinergic nervous system plays an important role in cognition, with
acetylcholine hypofunction considered to be a major factor of dementia. Botulinum toxin type …
acetylcholine hypofunction considered to be a major factor of dementia. Botulinum toxin type …
[HTML][HTML] Distribution of Cleaved SNAP-25 in the Rat Brain, following Unilateral Injection of Botulinum Neurotoxin-A into the Striatum
F Schümann, O Schmitt, A Wree… - International Journal of …, 2023 - mdpi.com
In Parkinson's disease, hypercholinism in the striatum occurs, with the consequence of
disturbed motor functions. Direct application of Botulinum neurotoxin-A in the striatum of …
disturbed motor functions. Direct application of Botulinum neurotoxin-A in the striatum of …
Interlinking potential therapy with botulinum neurotoxin-A and Parkinson's disease
A Wree, A Hawlitschka, C Holzmann, M Witt… - … and Management in …, 2020 - Elsevier
The predominant characteristic of Parkinson's disease is the loss of dopaminergic neurons
in the substantia nigra pars compacta and axonal degeneration of dopaminergic fibers in the …
in the substantia nigra pars compacta and axonal degeneration of dopaminergic fibers in the …
[HTML][HTML] Ungewöhnliche therapeutische Anwendungen von Botulinumtoxin
FJ Erbguth - Aktuelle Neurologie, 2015 - thieme-connect.com
Die muskellähmende Wirkung von Botulinumtoxin wurde in den 80er Jahren zunächst bei
kraniozervikalen Dystonien und beim Spasmus hemifacialis eingesetzt und 1993 in …
kraniozervikalen Dystonien und beim Spasmus hemifacialis eingesetzt und 1993 in …
The Behavioural Effects and Sept-Hippocampal Cholinergic Activity Changes Caused by Repeated Bont/A Injection on Facial Muscle in Adolescent Mice
X Xu, L Ni, D Sun, H Chen, Q Tang, S Cao… - A Injection on Facial … - papers.ssrn.com
Botulinum neurotoxin type A (BoNT/A) is a potent metalloprotease that acts primarily by
specifically cleavage of presynaptic synaptosomal-associated 25 kDa (SNAP-25) …
specifically cleavage of presynaptic synaptosomal-associated 25 kDa (SNAP-25) …