Overview of the 2022 WHO classification of neuroendocrine neoplasms

G Rindi, O Mete, S Uccella, O Basturk, S La Rosa… - Endocrine …, 2022 - Springer
In this review, we detail the changes and the relevant features that are applied to
neuroendocrine neoplasms (NENs) in the 2022 WHO Classification of Endocrine and …

Update from the 5th edition of the world health organization classification of head and neck tumors: overview of the 2022 WHO classification of head and neck …

O Mete, BM Wenig - Head and neck pathology, 2022 - Springer
This review article provides a brief overview of the new WHO classification by adopting a
question–answer model to highlight the spectrum of head and neck neuroendocrine …

[HTML][HTML] The complex histopathological and immunohistochemical spectrum of neuroendocrine tumors—An overview of the latest classifications

AA Gheorghișan-Gălățeanu, A Ilieșiu… - International Journal of …, 2023 - mdpi.com
Neuroendocrine neoplasms (NENs) originate from the neuroendocrine cell system, which
may either take the shape of organoid cell aggregations or be composed of dispersed cells …

[HTML][HTML] An analysis of 130 neuroendocrine tumors G3 regarding prevalence, origin, metastasis, and diagnostic features

A Kasajima, B Konukiewitz, AM Schlitter, W Weichert… - Virchows Archiv, 2022 - Springer
Limited data exist on high-grade neuroendocrine tumors (NETs G3) which represent a new
category among neuroendocrine neoplasms (NEN). We analyzed NETs G3 in a consultation …

[HTML][HTML] DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas and pancreatic neuroendocrine tumors

T Simon, P Riemer, A Jarosch, K Detjen… - Genome medicine, 2022 - Springer
Abstract Background Pancreatic neuroendocrine neoplasms (PanNENs) fall into two
subclasses: the well-differentiated, low-to high-grade pancreatic neuroendocrine tumors …

[HTML][HTML] Expert Consensus Practice Recommendations of the North American Neuroendocrine Tumor Society for the management of high grade …

JR Eads, TR Halfdanarson, T Asmis… - Endocrine-related …, 2023 - erc.bioscientifica.com
High-grade neuroendocrine neoplasms are a rare disease entity and account for
approximately 10% of all neuroendocrine neoplasms. Because of their rarity, there is an …

[HTML][HTML] Metastatic neuroendocrine neoplasms of unknown primary: clues from pathology workup

CC Juhlin, J Zedenius, A Höög - Cancers, 2022 - mdpi.com
Simple Summary While most neuroendocrine neoplasms are indolent and slow-growing
tumors, subsets of cases will spread beyond the tissue of origin. Given the rather slow …

Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract

H Wu, Z Yu, Y Liu, L Guo, L Teng, L Guo… - Cancer …, 2022 - Wiley Online Library
Background Neuroendocrine carcinomas of the gastrointestinal tract (GI‐NECs) remain a
disease of grim prognosis with limited therapeutic options. Their molecular characteristics …

[HTML][HTML] Challenges in high-grade neuroendocrine neoplasms and mixed neuroendocrine/non-neuroendocrine neoplasms

S La Rosa - Endocrine Pathology, 2021 - Springer
The growth in knowledge of the pathogenesis, molecular background, and
immunohistochemical profile of neuroendocrine neoplasms (NENs) has led not only to an …

Gastroenteropancreatic neuroendocrine neoplasms G3: Novel insights and unmet needs

M Shi, Z Fan, J Xu, J Yang, Y Li, C Gao, P Su… - … et Biophysica Acta (BBA …, 2021 - Elsevier
According to the 2019 WHO pathology grading system, high-grade gastroenteropancreatic
neuroendocrine neoplasms (GEP-NENs) can be divided into well differentiated …