In an earlier study, we reported that chronic ethanol (EtOH) stimulates the formation of
anandamide in human SK-N-SH cells. In the present study, we investigated the effect of …

Although many people drink alcohol regularly, only some become addicted. Several studies
have shown that genetic and environmental factors contribute to individual differences in the …

Extended access to cocaine produces an increase in cocaine self-administration in rats that
mimics aspects of compulsive drug intake in human addicts. Although emerging evidence …

Endocannabinoids (eCB) and cannabinoid receptor 1 (CB1) play important roles in
mediating short-and long-term synaptic plasticity in many brain regions involved in learning …

Ethanol increases extracellular anandamide levels in neuronal cells. However, the
molecular mechanisms by which this occurs are unknown. Chronic exposure of cerebellar …

The endogenous cannabinoid acylethanolamide AEA (arachidonoylethanolamide; also
known as anandamide) participates in the neuroadaptations associated with chronic ethanol …

This review presents the remarkable advances that have been achieved in marijuana
(cannabinoid) research, with the discovery of specific receptors and the existence of …

Alcohol use disorder represents a significant human health problem that leads to substantial
loss of human life and financial cost to society. Currently available treatment options do not …

Alcohol use disorder (AUD) is highly comorbid with traumatic brain injury (TBI). Previously,
using a lateral fluid percussion model (LFP)(an open-head injury model) to generate a …

The present study evaluates the pharmacological profile of the new neutral cannabinoid
CB1 receptor antagonist 5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-3-hexyl-1H-1, 2, 4 …