Background: The hippocampus is strongly implicated in memory processes and contains
high concentrations of both cannabinoid receptors and their endogenous ligands. Chronic …

Background Stressful episodes and high alcohol consumption during adolescence are
considered major risk factors for the development of psychiatric disorders in adulthood …

Background: Endogenous cannabinoids such as anandamide and 2‐arachidonoylglycerol
(2‐AG) exert important regulatory influences on neuronal signaling, participate in short‐and …

Alcohol dependence is associated with anxiety during withdrawal. The endocannabinoid
(ECB) system participates in the neuroendocrine and behavioral response to stress and …

Abstract Δ 9-tetrahydrocannabinol (Δ 9-THC), the primary active component in Cannabis
sativa preparations such as hashish and marijuana, signals by binding to cell surface …

Δ9‐tetrahydrocannabinol, the principal active component in Cannabis sativa extracts such
as marijuana, participates in cell signalling by binding to cannabinoid CB1 and CB2 …

Highlights•Disruption of HPA axis leads to reward system hypofunction in alcohol
dependence.•Extrahypothalamic stress systems are sensitized in alcohol dependence.•Loss …

Aims: The aim of this study was to examine the effects of chronic ethanol consumption in
cannabinoid CB1 receptor gene expression in Wistar rats. Methods: Rats were exposed to a …

A lot of evidence indicate that endocannabinoids and cannabinoid CB receptors are
implicated in drug addiction. In the present study, we investigated the effect of the …

The present review evaluates the evidence that the endocannabinoid system plays in the
development of tolerance to alcohol. The identification of a G-protein-coupled receptor …