Inhaled corticosteroids in COPD: friend or foe?

A Agusti, LM Fabbri, D Singh, J Vestbo… - European …, 2018 - Eur Respiratory Soc
The efficacy, safety and positioning of inhaled corticosteroids (ICS) in the treatment of
patients with chronic obstructive pulmonary disease (COPD) is much debated, since it can …

[HTML][HTML] Pulmonary-intestinal cross-talk in mucosal inflammatory disease

S Keely, NJ Talley, PM Hansbro - Mucosal immunology, 2012 - Elsevier
Chronic obstructive pulmonary disease (COPD) and inflammatory bowel diseases (IBDs)
are chronic inflammatory diseases of mucosal tissues that affect the respiratory and …

Extrafine inhaled triple therapy versus dual bronchodilator therapy in chronic obstructive pulmonary disease (TRIBUTE): a double-blind, parallel group, randomised …

A Papi, J Vestbo, L Fabbri, M Corradi, H Prunier… - The Lancet, 2018 - thelancet.com
Background Evidence is scarce on the relative risk-benefit of inhaled triple therapy,
consisting of inhaled corticosteroid, long-acting muscarinic antagonist, and long-acting β 2 …

Triple therapy with budesonide/glycopyrrolate/formoterol fumarate with co-suspension delivery technology versus dual therapies in chronic obstructive pulmonary …

GT Ferguson, KF Rabe, FJ Martinez… - The Lancet …, 2018 - thelancet.com
Background Inhaled corticosteroids have been used in patients with chronic obstructive
pulmonary disease (COPD), but the potential benefits of their use in triple therapy are not …

[HTML][HTML] Mepolizumab for eosinophilic chronic obstructive pulmonary disease

ID Pavord, P Chanez, GJ Criner… - … England Journal of …, 2017 - Mass Medical Soc
Background Patients with chronic obstructive pulmonary disease (COPD) with an
eosinophilic phenotype may benefit from treatment with mepolizumab, a monoclonal …

[HTML][HTML] Indacaterol–glycopyrronium versus salmeterol–fluticasone for COPD

JA Wedzicha, D Banerji, KR Chapman… - … England Journal of …, 2016 - Mass Medical Soc
Background Most guidelines recommend either a long-acting beta-agonist (LABA) plus an
inhaled glucocorticoid or a long-acting muscarinic antagonist (LAMA) as the first-choice …

Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease …

S Pascoe, N Locantore, MT Dransfield… - The lancet Respiratory …, 2015 - thelancet.com
Background The short-term benefits of inhaled corticosteroids for patients with chronic
obstructive pulmonary disease (COPD) are greater in patients with evidence of eosinophilic …

Fluticasone furoate and vilanterol and survival in chronic obstructive pulmonary disease with heightened cardiovascular risk (SUMMIT): a double-blind randomised …

J Vestbo, JA Anderson, RD Brook, PMA Calverley… - The Lancet, 2016 - thelancet.com
Background Chronic obstructive pulmonary disease (COPD) often coexists with
cardiovascular disease. Treatments for airflow limitation might improve survival and both …

Risk of COVID-19-related death among patients with chronic obstructive pulmonary disease or asthma prescribed inhaled corticosteroids: an observational cohort …

A Schultze, AJ Walker, B MacKenna… - The Lancet …, 2020 - thelancet.com
Background Early descriptions of patients admitted to hospital during the COVID-19
pandemic showed a lower prevalence of asthma and chronic obstructive pulmonary disease …

Blood eosinophils and inhaled corticosteroid/long-acting β-2 agonist efficacy in COPD

ID Pavord, S Lettis, N Locantore, S Pascoe, PW Jones… - Thorax, 2016 - thorax.bmj.com
Objective We performed a review of studies of fluticasone propionate (FP)/salmeterol
(SAL)(combination inhaled corticosteroid (ICS)/long-acting β2-agonist (LABA)) in patients …