Serotonin 2A Receptor (5-HT2AR) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants

W Duan, D Cao, S Wang, J Cheng - Chemical Reviews, 2023 - ACS Publications
Psychedelics make up a group of psychoactive compounds that induce hallucinogenic
effects by activating the serotonin 2A receptor (5-HT2AR). Clinical trials have demonstrated …

Molecular biology of 5-HT receptors

FG Boess, IL Martin - Neuropharmacology, 1994 - Elsevier
The receptors through which serotonin (5-hydroxytryptamine, 5-HT) produces its effects
have been the subject of intense investigation, initially using both in vivo and in vitro …

Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine

PB Bradley, G Engel, W Feniuk, JR Fozard… - …, 1986 - Elsevier
As a result of controversy in the literature regarding the classification and nomenclature of
functional receptors for 5-hydroxytryptamine (5-HT), a framework for classification is …

Serotonin receptors in the human brain—IV. Autoradiographic mapping of serotonin-2 receptors

A Pazos, A Probst, JM Palacios - Neuroscience, 1987 - Elsevier
The anatomical distribution of serotonin-2 receptors in the human brain was studied by light
microscopic autoradiography, using [3 H] ketanserin as a ligand. The receptor densities …

Psychedelics: preclinical insights provide directions for future research

RH Gumpper, BL Roth - Neuropsychopharmacology, 2024 - nature.com
Recently, psychedelics have emerged as promising therapeutics for numerous
neuropsychiatric disorders. While their potential in the clinic has yet to be fully elucidated …

Mismatches between neurotransmitter and receptor localizations in brain: observations and implications

M Herkenham - Neuroscience, 1987 - Elsevier
3. II Limitations for immunocytochemistry 3.1. 2. Receptor autoradiography artifacts 3.2.
Transmitters and receptors distributed throughout different neurons 3.2. I. Transmitter is …

Receptor-binding properties in vitro and in vivo of ritanserin: A very potent and long acting serotonin-S2 antagonist.

JE Leysen, W Gommeren, P Van Gompel… - Molecular …, 1985 - ASPET
In vitro and in vivo receptor-binding properties of the new serotonin antagonist, ritanserin,
are reported. In in vitro binding assays, ritanserin shows high affinity binding to serotonin-S2 …

The hyperserotonemia of autism.

GM Anderson, WC Horne, D Chatterjee… - Annals of the New York …, 1990 - europepmc.org
The planned and ongoing studies of platelet function and composition should allow us to
better define the alteration which we presume to be present in platelets of autistic subjects …

Structure and functional expression of cloned rat serotonin 5HT‐2 receptor.

DB Pritchett, AW Bach, M Wozny, O Taleb… - The EMBO …, 1988 - embopress.org
A complementary DNA (cDNA) encoding a serotonin receptor with 51% sequence identity to
the 5HT‐1C subtype was isolated from a rat brain cDNA library by homology screening …

Serotonin and anxiety revisited

RS Kahn, HM Van Praag, S Wetzler, GM Asnis… - Biological Psychiatry, 1988 - Elsevier
Serotonin (5hydroxytryptamine; 5-HT) was first discovered in 1948 in blood platelets and a
few years later in the brain. Since then, investigations of 5-HT involvement in mental …