Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer's
disease have created excitement and have been heralded as corroboration of the amyloid …

Reactive species produced in the cell during normal cellular metabolism can chemically
react with cellular biomolecules such as nucleic acids, proteins, and lipids, thereby causing …

Several lines of recent evidence indicate that the amyloid precursor protein-derived C-
terminal fragments (APP-CTFs) could correspond to an etiological trigger of Alzheimer's …

Protein corona presents a major obstacle to bench-to-bedside translation of targeted drug
delivery systems, severely affecting targeting yields and directing unfavorable …

The amyloid hypothesis has driven drug development strategies for Alzheimer's disease for
over 20 years. We review why accumulation of amyloid-beta (Aβ) oligomers is generally …

Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the
accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated …

Traumatic brain injury (TBI) remains one of the leading causes of mortality and morbidity
worldwide, yet despite extensive efforts to develop neuroprotective therapies for this …

Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of
the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both …

The amyloid cascade hypothesis is widely accepted as the centerpiece of Alzheimer
disease (AD) pathogenesis. It proposes that abnormal production of beta amyloid protein …