Mitochondria are well known as 'the powerhouses of the cell'. Indeed, their major role is
cellular energy production driven by both mitochondrial and nuclear DNA. Such a feature …

Germ cell formation and embryonic development require ATP synthesized by mitochondria.
The dynamic system of the mitochondria, and in particular, the fusion of mitochondria, are …

In mammalian ovaries, oocytes are physically coupled to somatic granulosa cells, and this
coupling is crucial for the growth and development of competent oocytes as it mediates the …

The development of oocytes and early embryos is dependent on mitochondrial ATP
production. This reliance on mitochondrial activity, together with the exclusively maternal …

In vivo and in vitro studies demonstrate that mitochondria in the oocyte, are susceptible to
damage by suboptimal pre/pregnancy conditions, such as obesity. These suboptimal …

Until recently it was thought that most humans only harbor one type of mitochondrial DNA
(mtDNA), however, deep sequencing and single-cell analysis has shown the converse–that …

Mitochondrial dysfunction plays a crucial role in the pathological physiology of polycystic
ovary syndrome (PCOS). Mitochondrial quality control system is vital to maintaining …

Follicular microenvironment is paramount in the acquisition of oocyte competence, which is
dependent on two interconnected and interdependent processes: nuclear and cytoplasmic …

Mitochondrial dysfunction is widely implicated in various human diseases, through
mechanisms that go beyond mitochondria's well-established role in energy generation …

We have previously reported that juglone, a natural compound found in Juglandaceae with
a wide range of biological activities, can reduces the developmental competence of bovine …