The Evolving Landscape of Antibody–Drug Conjugates: In Depth Analysis of Recent Research Progress
Antibody–drug conjugates (ADCs) are targeted immunoconjugate constructs that integrate
the potency of cytotoxic drugs with the selectivity of monoclonal antibodies, minimizing …
the potency of cytotoxic drugs with the selectivity of monoclonal antibodies, minimizing …
Polymeric Nanoparticles for Drug Delivery
MA Beach, U Nayanathara, Y Gao, C Zhang… - Chemical …, 2024 - ACS Publications
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …
necessitated the creation of more sophisticated drug delivery systems. Polymeric …
Emerging Trends in the Chemistry of End-to-End Depolymerization
Z Deng, ER Gillies - JACS Au, 2023 - ACS Publications
Over the past couple of decades, polymers that depolymerize end-to-end upon cleavage of
their backbone or activation of a terminal functional group, sometimes referred to as “self …
their backbone or activation of a terminal functional group, sometimes referred to as “self …
Grafting self-immolative poly (benzyl ether) s toward sustainable adhesive thermosets with reversible bonding and triggered de-bonding capabilities
B Choi, JW Kim, G Choi, S Jeong, E Choi… - Journal of Materials …, 2023 - pubs.rsc.org
This paper demonstrates a molecular design concept for stimuli-responsive polymer
adhesives. Self-immolative poly (benzyl ether)(PBE) is synthesized as a functional macro …
adhesives. Self-immolative poly (benzyl ether)(PBE) is synthesized as a functional macro …
[HTML][HTML] Induced-volatolomics for the design of tumour activated therapy
R Châtre, E Blochouse, R Eid, F Djago, J Lange… - Chemical …, 2023 - pubs.rsc.org
The discovery of tumour-associated markers is of major interest for the development of
selective cancer chemotherapy. Within this framework, we introduced the concept of induced …
selective cancer chemotherapy. Within this framework, we introduced the concept of induced …
Controlled Ring-Opening Polymerization of Macrocyclic Monomers Based on Ring-Opening/Ring-Closing Cascade Reaction
W Chen, C Guo, H Ding, X Yang… - Journal of the American …, 2023 - ACS Publications
The development of a controlled ring-opening polymerization (ROP) method for synthesizing
backbone-functionalized and sequence-controlled polymers with well-defined architectures …
backbone-functionalized and sequence-controlled polymers with well-defined architectures …
Conjugated Polymers with Self‐Immolative Sidechain Linkers for Carbon Nanotube Dispersion
X Yu, A Adronov - Small, 2024 - Wiley Online Library
Single‐walled carbon nanotubes (SWNTs) are promising materials for generating high‐
performance electronic devices. However, these applications are greatly restricted by their …
performance electronic devices. However, these applications are greatly restricted by their …
Stimuli‐accelerated polymeric drug delivery systems
T Rust, D Jung, K Langer, D Kuckling - Polymer International, 2023 - Wiley Online Library
The controlled delivery of active pharmaceutical ingredients to the site of disease represents
a major challenge in drug therapy. Particularly when drugs have to be transported across …
a major challenge in drug therapy. Particularly when drugs have to be transported across …
Bioorthogonal drug release from nanometric micelles in living cells
L Madegard, M Girard, BR Yaw, K Porte… - … A European Journal, 2023 - Wiley Online Library
We explored a bioorthogonal approach to release drugs from stimuli‐responsive micelles
inside tumor cells. The concept relies on sydnonimine‐based micelles that undergo …
inside tumor cells. The concept relies on sydnonimine‐based micelles that undergo …
A Platform Approach to Cleavable Macrocycles for the Controlled Disassembly of Mechanically Caged Molecules
A Saady, GK Malcolm, MP Fitzpatrick… - Angewandte Chemie …, 2024 - Wiley Online Library
Inspired by interlocked oligonucleotides, peptides and knotted proteins, synthetic systems
where a macrocycle cages a bioactive species that is “switched on” by breaking the …
where a macrocycle cages a bioactive species that is “switched on” by breaking the …