[HTML][HTML] Dopamine in autism spectrum disorders—focus on D2/D3 partial agonists and their possible use in treatment

V Mandic-Maravic, R Grujicic, L Milutinovic… - Frontiers in …, 2022 - frontiersin.org
Autism spectrum disorders (ASD) are a group of disorders characterized by impairment in
social communication and repetitive and stereotyped behaviors. ASD etiology is very …

Phytocannabinoids and schizophrenia: Focus on adolescence as a critical window of enhanced vulnerability and opportunity for treatment

T Stark, S Di Martino, F Drago, CT Wotjak… - Pharmacological …, 2021 - Elsevier
The recent shift in socio-political debates and growing liberalization of Cannabis use across
the globe has raised concern regarding its impact on vulnerable populations such as …

[HTML][HTML] PharmacoSTORM nanoscale pharmacology reveals cariprazine binding on Islands of Calleja granule cells

S Prokop, P Ábrányi-Balogh, B Barti, M Vámosi… - Nature …, 2021 - nature.com
Immunolabeling and autoradiography have traditionally been applied as the methods-of-
choice to visualize and collect molecular information about physiological and pathological …

[HTML][HTML] Progress and pitfalls in developing agents to treat neurocognitive deficits associated with schizophrenia

T Veselinović, I Neuner - CNS drugs, 2022 - Springer
Cognitive impairments associated with schizophrenia (CIAS) represent a central element of
the symptomatology of this severe mental disorder. CIAS substantially determine the …

[HTML][HTML] The missing hallmark of health: psychosocial adaptation

C López-Otín, G Kroemer - Cell Stress, 2024 - ncbi.nlm.nih.gov
The eight biological hallmarks of health that we initially postulated (Cell. 2021 Jan 7; 184 (1):
33-63) include features of spatial compartmentalization (integrity of barriers, containment of …

[HTML][HTML] Unveiling the Differences in Signaling and Regulatory Mechanisms between Dopamine D2 and D3 Receptors and Their Impact on Behavioral Sensitization

KM Kim - International Journal of Molecular Sciences, 2023 - mdpi.com
Dopamine receptors are classified into five subtypes, with D2R and D3R playing a crucial
role in regulating mood, motivation, reward, and movement. Whereas D2R are distributed …

[HTML][HTML] Canonical and non-canonical antipsychotics' dopamine-related mechanisms of present and next generation molecules: a systematic review on translational …

A de Bartolomeis, M Ciccarelli, G De Simone… - International Journal of …, 2023 - mdpi.com
Schizophrenia is a severe psychiatric illness affecting almost 25 million people worldwide
and is conceptualized as a disorder of synaptic plasticity and brain connectivity …

[HTML][HTML] Improving mood and cognitive symptoms in Huntington's disease with cariprazine treatment

MJ Molnar, V Molnar, M Fedor, R Csehi, K Acsai… - Frontiers in …, 2022 - frontiersin.org
In Huntington's disease (HD), the main clinical symptoms include depression, apathy,
cognitive deficits, motor deficiencies and involuntary movements. Cognitive, mood and …

[HTML][HTML] Assessing NH300094, a novel dopamine and serotonin receptor modulator with cognitive enhancement property for treating schizophrenia

Z Feng, Z Hu, L Li, M Yu, Y Zhang, P Jing… - Frontiers in …, 2024 - frontiersin.org
Background: Schizophrenia is a serious psychiatric disorder that significantly affects the
quality of life of patients. The objective of this study is to discover a novel antipsychotic …

[HTML][HTML] Potential Mechanisms for Why Not All Antipsychotics Are Able to Occupy Dopamine D3 Receptors in the Brain in vivo

B Kiss, B Krámos, I Laszlovszky - Frontiers in Psychiatry, 2022 - frontiersin.org
Dysfunctions of the dopaminergic system are believed to play a major role in the core
symptoms of schizophrenia such as positive, negative, and cognitive symptoms. The first line …