The transition between epithelial and mesenchymal phenotype is emerging as a key
determinant of tumor cell invasion and metastasis. It is a plastic process in which epithelial …

Iron is an essential trace element for the human body, and its deficiency or excess can
induce a variety of biological processes. Plenty of evidences have shown that iron …

Magnetic hyperthermia therapy (MHT) is a promising new modality to deal with solid tumors,
yet the low magnetic-heat conversion efficacy, magnetic resonance imaging (MRI) artifacts …

During the past three decades, mice, zebrafish, fruit flies, and Caenorhabditis elegans have
been the primary model organisms used for the study of various biological phenomena …

Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …

Simple Summary Tumor hypoxia remains a significant problem in the effective treatment of
most cancers. Tumor cells within hypoxic niches tend to be largely resistant to most …

Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins
that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide …

The emerging tumor ferroptosis therapy confronts impediments of the tumor
microenvironment (TME) with weak intrinsic acidity, inadequate endogenous H2O2, and a …

The primary physiological process of respiration produces carbon dioxide (CO 2) that reacts
with water molecules which subsequently liberates bicarbonate (HCO–3) and protons …

The microenvironment in solid tumors drives the fate of cancer cells to ferroptosis, yet the
underlying mechanism remains incompletely understood. Herein, we report a metal-free …