Advanced models for respiratory disease and drug studies

J Shrestha, KR Paudel, H Nazari… - Medicinal Research …, 2023 - Wiley Online Library
The global burden of respiratory diseases is enormous, with many millions of people
suffering and dying prematurely every year. The global COVID‐19 pandemic witnessed …

[HTML][HTML] Application of ovarian cancer organoids in precision medicine: key challenges and current opportunities

J Yang, S Huang, S Cheng, Y Jin, N Zhang… - Frontiers in cell and …, 2021 - frontiersin.org
Ovarian cancer (OC) is the leading cause of death among gynecologic malignances. Over
the past decades, human-derived models have advanced from monolayer cell cultures to …

Organoid technology in cancer precision medicine

X Xia, F Li, J He, R Aji, D Gao - Cancer letters, 2019 - Elsevier
Organoid technology has been remarkably improved over the last decade. Various
organoids have been derived from different types of tissues and recapitulate their organ …

[HTML][HTML] Culture of patient-derived multicellular clusters in suspended hydrogel capsules for pre-clinical personalized drug screening

H Dong, Z Li, S Bian, G Song, W Song, M Zhang… - Bioactive materials, 2022 - Elsevier
A personalized medication regimen provides precise treatment for an individual and can be
guided by pre-clinical drug screening. The economical and high-efficiency simulation of the …

[HTML][HTML] Organoid transplantation can improve reproductive prognosis by promoting endometrial repair in mice

H Zhang, D Xu, Y Li, J Lan, Y Zhu, J Cao… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Objective: Intrauterine adhesion (IUA) is one of the major causes of refractory secondary
infertility, especially in regions and countries with high abortion rates. In this study, we used …

[HTML][HTML] Studying kidney diseases using organoid models

M Liu, A Cardilla, J Ngeow, X Gong… - Frontiers in cell and …, 2022 - frontiersin.org
The prevalence of chronic kidney disease (CKD) is rapidly increasing over the last few
decades, owing to the global increase in diabetes, and cardiovascular diseases. Dialysis …

[HTML][HTML] Cultivation of clear cell renal cell carcinoma patient-derived organoids in an air-liquid interface system as a tool for studying individualized therapy

LK Esser, V Branchi, S Leonardelli, N Pelusi… - Frontiers in …, 2020 - frontiersin.org
Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer accounting for
80% of all renal cancers as well as the majority of renal cancer-associated deaths. During …

[HTML][HTML] Current advances of stem cell-based therapy for kidney diseases

CY Wong - World journal of stem cells, 2021 - ncbi.nlm.nih.gov
Kidney diseases are a prevalent health problem around the world. Multidrug therapy used in
the current routine treatment for kidney diseases can only delay disease progression. None …

A pancreatic cancer organoid platform identifies an inhibitor specific to mutant KRAS

X Duan, T Zhang, L Feng, N de Silva, B Greenspun… - Cell Stem Cell, 2024 - cell.com
Summary KRAS mutations, mainly G12D and G12V, are found in more than 90% of
pancreatic ductal adenocarcinoma (PDAC) cases. The success of drugs targeting KRAS …

[HTML][HTML] Tumor organoid and spheroid models for cervical cancer

I Kutle, R Polten, J Hachenberg, R Klapdor, M Morgan… - Cancers, 2023 - mdpi.com
Simple Summary Appropriate testing models are imperative to facilitate the discovery of
effective personalized treatments against different cancers, including advanced cervical …