Advanced models for respiratory disease and drug studies
The global burden of respiratory diseases is enormous, with many millions of people
suffering and dying prematurely every year. The global COVID‐19 pandemic witnessed …
suffering and dying prematurely every year. The global COVID‐19 pandemic witnessed …
[HTML][HTML] Application of ovarian cancer organoids in precision medicine: key challenges and current opportunities
J Yang, S Huang, S Cheng, Y Jin, N Zhang… - Frontiers in cell and …, 2021 - frontiersin.org
Ovarian cancer (OC) is the leading cause of death among gynecologic malignances. Over
the past decades, human-derived models have advanced from monolayer cell cultures to …
the past decades, human-derived models have advanced from monolayer cell cultures to …
Organoid technology in cancer precision medicine
X Xia, F Li, J He, R Aji, D Gao - Cancer letters, 2019 - Elsevier
Organoid technology has been remarkably improved over the last decade. Various
organoids have been derived from different types of tissues and recapitulate their organ …
organoids have been derived from different types of tissues and recapitulate their organ …
[HTML][HTML] Culture of patient-derived multicellular clusters in suspended hydrogel capsules for pre-clinical personalized drug screening
H Dong, Z Li, S Bian, G Song, W Song, M Zhang… - Bioactive materials, 2022 - Elsevier
A personalized medication regimen provides precise treatment for an individual and can be
guided by pre-clinical drug screening. The economical and high-efficiency simulation of the …
guided by pre-clinical drug screening. The economical and high-efficiency simulation of the …
[HTML][HTML] Organoid transplantation can improve reproductive prognosis by promoting endometrial repair in mice
H Zhang, D Xu, Y Li, J Lan, Y Zhu, J Cao… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Objective: Intrauterine adhesion (IUA) is one of the major causes of refractory secondary
infertility, especially in regions and countries with high abortion rates. In this study, we used …
infertility, especially in regions and countries with high abortion rates. In this study, we used …
[HTML][HTML] Studying kidney diseases using organoid models
The prevalence of chronic kidney disease (CKD) is rapidly increasing over the last few
decades, owing to the global increase in diabetes, and cardiovascular diseases. Dialysis …
decades, owing to the global increase in diabetes, and cardiovascular diseases. Dialysis …
[HTML][HTML] Cultivation of clear cell renal cell carcinoma patient-derived organoids in an air-liquid interface system as a tool for studying individualized therapy
LK Esser, V Branchi, S Leonardelli, N Pelusi… - Frontiers in …, 2020 - frontiersin.org
Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer accounting for
80% of all renal cancers as well as the majority of renal cancer-associated deaths. During …
80% of all renal cancers as well as the majority of renal cancer-associated deaths. During …
[HTML][HTML] Current advances of stem cell-based therapy for kidney diseases
CY Wong - World journal of stem cells, 2021 - ncbi.nlm.nih.gov
Kidney diseases are a prevalent health problem around the world. Multidrug therapy used in
the current routine treatment for kidney diseases can only delay disease progression. None …
the current routine treatment for kidney diseases can only delay disease progression. None …
A pancreatic cancer organoid platform identifies an inhibitor specific to mutant KRAS
Summary KRAS mutations, mainly G12D and G12V, are found in more than 90% of
pancreatic ductal adenocarcinoma (PDAC) cases. The success of drugs targeting KRAS …
pancreatic ductal adenocarcinoma (PDAC) cases. The success of drugs targeting KRAS …
[HTML][HTML] Tumor organoid and spheroid models for cervical cancer
I Kutle, R Polten, J Hachenberg, R Klapdor, M Morgan… - Cancers, 2023 - mdpi.com
Simple Summary Appropriate testing models are imperative to facilitate the discovery of
effective personalized treatments against different cancers, including advanced cervical …
effective personalized treatments against different cancers, including advanced cervical …