Current status of organoid culture in urological malignancy
Urological cancers are common malignancies worldwide. Several conventional models, for
example, two‐dimensional cell culture and animal models have been used for decades to …
example, two‐dimensional cell culture and animal models have been used for decades to …
The anti-angiogenic tyrosine kinase inhibitor Pazopanib kills cancer cells and disrupts endothelial networks in biomimetic three-dimensional renal tumouroids
K Stamati, PA Redondo, A Nyga… - Journal of tissue …, 2020 - journals.sagepub.com
Pazopanib is a tyrosine kinase inhibitor used to treat renal cell carcinoma. Few in vitro
studies investigate its effects towards cancer cells or endothelial cells in the presence of …
studies investigate its effects towards cancer cells or endothelial cells in the presence of …
Impact of andrographolide and melatonin combinatorial drug therapy on metastatic colon cancer cells and organoids
N Sharda, T Ikuse, E Hill, S Garcia… - Clinical Medicine …, 2021 - journals.sagepub.com
Background: The death rate (the number of deaths per 100 000 people per year) of
colorectal cancer (CRC) has been dropping since 1980 due to increased screening, lifestyle …
colorectal cancer (CRC) has been dropping since 1980 due to increased screening, lifestyle …
[HTML][HTML] Establishment of a ccRCC patient-derived chick chorioallantoic membrane model for drug testing
M Charbonneau, K Harper, K Brochu-Gaudreau… - Frontiers in …, 2022 - frontiersin.org
Clear cell renal cell carcinoma (ccRCC) is an aggressive subtype of renal cell carcinoma
accounting for the majority of deaths in kidney cancer patients. Advanced ccRCC has a high …
accounting for the majority of deaths in kidney cancer patients. Advanced ccRCC has a high …
[HTML][HTML] Kidney Cancer Models for Pre-Clinical Drug Discovery: Challenges and Opportunities
L Pohl, J Friedhoff, C Jurcic, M Teroerde… - Frontiers in …, 2022 - frontiersin.org
Renal cell carcinoma (RCC) is among the most lethal urological malignancies once
metastatic. The introduction of immune checkpoint inhibitors has revolutionized the …
metastatic. The introduction of immune checkpoint inhibitors has revolutionized the …
整合设计策略下的工程化类器官与类器官芯片技术
胡可儿， 王汉奇， 黄儒麒， 张灿阳， 邢新会， 马少华 - 合成生物学, 2024 - synbioj.cip.com.cn
类器官和类器官芯片技术是一种由干细胞或特定类型的细胞在体外培养而成的模拟真实器官
功能和微环境的三维组织结构, 帮助研究者更准确地研究生物过程, 疾病机制 …
功能和微环境的三维组织结构, 帮助研究者更准确地研究生物过程, 疾病机制 …
[HTML][HTML] Landscape of human organoids: Ideal model in clinics and research
X Han, C Cai, W Deng, Y Shi, L Li, C Wang… - The …, 2024 - ncbi.nlm.nih.gov
In the last decade, organoid research has entered a golden era, signifying a pivotal shift in
the biomedical landscape. The year 2023 marked a milestone with the publication of …
the biomedical landscape. The year 2023 marked a milestone with the publication of …
[PDF][PDF] Recent advances and challenges in organoid-on-a-chip technology
Conventional 2-dimensional cell culture poorly mimics human-relevant models, which is
considered a major challenge in biological research. Organoids are a recent breakthrough …
considered a major challenge in biological research. Organoids are a recent breakthrough …
Generation of human kidney tubuloids from tissue and urine
C Calandrini, J Drost - JoVE (Journal of Visualized Experiments), 2021 - jove.com
Adult stem cell (ASC)-derived human kidney epithelial organoids, or tubuloids, can be
established from healthy and diseased kidney epithelium with high efficiency. Normal kidney …
established from healthy and diseased kidney epithelium with high efficiency. Normal kidney …
[HTML][HTML] Phenotypical screening on metastatic PRCC-TFE3 fusion translocation renal cell carcinoma organoids reveals potential therapeutic agents
C Cao, X Lan, B Shang, W Jiang, L Guo… - Clinical and …, 2022 - Springer
Purpose Translocation renal cell carcinoma (tRCC) is a subtype that occurs predominantly
in children and young individuals. Metastatic tRCC occurring in young patients is more …
in children and young individuals. Metastatic tRCC occurring in young patients is more …