Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Nitric oxide (NO) is undoubtedly quite an important intercellular messenger in cerebral and
peripheral hemodynamics. This molecule, formed by constitutive isomers of NO synthase …

Unanticipated, novel hypothesis on nitric oxide (NO) radical, an inorganic, labile, gaseous
molecule, as a neurotransmitter first appeared in late 1989 and into the early 1990s, and …

Intact, coordinated, and precisely regulated cerebrovascular responses are required for the
maintenance of cerebral metabolic homeostasis, adequate perfusion, oxygen delivery, and …

Abstract CONTINUOUS OXYGEN DELIVERY and CO 2 clearance are paramount in the
maintenance of normal brain function and tissue integrity. Under normal conditions, aerobic …

Memory processing requires tightly controlled signalling cascades, many of which are
dependent upon intracellular calcium (Ca2+). Despite this, most work investigating calcium …

Nitric oxide is a ubiquitous intercellular messenger involved in particular functions in the
cardiovascular, immunological and nervous systems. In the cerebral cortex, nitric oxide is …

Following the discovery of the vasorelaxant properties of nitric oxide (NO) by Furchgott and
Ignarro, the finding by Bredt and coll. of a constitutively expressed NO synthase in neurons …

The vasodilating capability of cerebral vessels is vital to brain survival. There are multiple
mechanisms participating in the regulation of cerebral vascular smooth muscle relaxation …

New Findings What is the topic of this review? Cerebrovascular reactivity to CO2, which is a
principal factor in determining ventilatory responses to CO2 through the role reactivity plays …