The evolutionary tug-of-war of macrophage metabolism during bacterial infection
The function and phenotype of macrophages are intimately linked with pathogen detection.
On sensing pathogen-derived signals and molecules, macrophages undergo a carefully …
On sensing pathogen-derived signals and molecules, macrophages undergo a carefully …
[HTML][HTML] Trained immunity-inducing vaccines: Harnessing innate memory for vaccine design and delivery
While the efficacy of many current vaccines is well-established, various factors can diminish
their effectiveness, particularly in vulnerable groups. Amidst emerging pandemic threats …
their effectiveness, particularly in vulnerable groups. Amidst emerging pandemic threats …
Multi-omics analysis reveals that linoleic acid metabolism is associated with variations of trained immunity induced by distinct BCG strains
JC Xu, ZY Chen, XJ Huang, J Wu, H Huang, LF Niu… - Science …, 2024 - science.org
Trained immunity is one of the mechanisms by which BCG vaccination confers persistent
nonspecific protection against diverse diseases. Genomic differences between the different …
nonspecific protection against diverse diseases. Genomic differences between the different …
Itaconate in host inflammation and defense
Immune cells undergo rapid and extensive metabolic changes during inflammation. In
addition to contributing to energetic and biosynthetic demands, metabolites can also …
addition to contributing to energetic and biosynthetic demands, metabolites can also …
Inducible antibacterial responses in macrophages
MJ Sweet, D Ramnath, A Singhal… - Nature Reviews …, 2024 - nature.com
Macrophages destroy bacteria and other microorganisms through phagocytosis-coupled
antimicrobial responses, such as the generation of reactive oxygen species and the delivery …
antimicrobial responses, such as the generation of reactive oxygen species and the delivery …
Basic mechanisms of Immunometabolites in shaping the immune response
Background: Innate immune cells play a crucial role in responding to microbial infections,
but their improper activation can also drive inflammatory disease. For this reason, their …
but their improper activation can also drive inflammatory disease. For this reason, their …
Metabolic Regulation in the Induction of Trained Immunity
AV Ferreira, J Domínguez-Andrés… - Seminars in …, 2024 - Springer
The innate immune system exhibits features of memory, termed trained immunity, which
promote faster and more robust responsiveness to heterologous challenges. Innate immune …
promote faster and more robust responsiveness to heterologous challenges. Innate immune …
Immunometabolism in atherosclerotic disorders
AJ Fleetwood, J Noonan, N La Gruta… - Nature Cardiovascular …, 2024 - nature.com
Cardiovascular diseases (CVDs), including atherosclerosis, myocardial infarction and heart
failure, are the leading causes of morbidity and mortality worldwide. Emerging evidence …
failure, are the leading causes of morbidity and mortality worldwide. Emerging evidence …
Control of immune cell signaling by the immuno-metabolite itaconate
R Lang, MNAA Siddique - Frontiers in Immunology, 2024 - frontiersin.org
Immune cell activation triggers signaling cascades leading to transcriptional reprogramming,
but also strongly impacts on the cell's metabolic activity to provide energy and biomolecules …
but also strongly impacts on the cell's metabolic activity to provide energy and biomolecules …
Metabolic regulation of the host–fungus interaction: from biological principles to therapeutic opportunities
R Silva-Gomes, I Caldeira, R Fernandes, C Cunha… - 2024 - academic.oup.com
Fungal infections present a significant global public health concern, impacting over 1 billion
individuals worldwide and resulting in more than 3 million deaths annually. Despite …
individuals worldwide and resulting in more than 3 million deaths annually. Despite …