Abstract Cyclooxygenase‐2 (COX‐2) is frequently expressed in many types of cancers
exerting a pleiotropic and multifaceted role in genesis or promotion of carcinogenesis and …

For centuries, nonsteroidal anti-inflammatory drugs (NSAIDs) have been part of our clinical
practice. They started out as drugs with anti-inflammatory and analgesic action, and …

The chaperone GRP78/Dna K is conserved throughout evolution down to prokaryotes. The
GRP78 inhibitor OSU‐03012 (AR‐12) interacted with sildenafil (Viagra) or tadalafil (Cialis) …

A drawback of extensive coxib use for antitumor purposes is the risk of life-threatening side
effects that are thought to be a class effect and probably due to the resulting imbalance of …

Colorectal cancer (CRC) is one of the main causes of cancer-related deaths worldwide.
Sporadic CRC develops from normal mucosa via adenoma to adenocarcinoma, which …

Colorectal cancer (CRC) is, for sporadic forms, most strongly related to lifestyle factors. The
epidemic of obesity and physical inactivity has great impact on disease patterns. Likewise …

Nonsteroidal anti-inflammatory drugs (NSAID) display promising antineoplastic activity, but
toxicity resulting from cyclooxygenase (COX) inhibition limits their clinical use for …

Colorectal cancer (CRC) is the fourth most common cause of death from cancer in the world.
The limitations of the currently available methods and biomarkers for CRC management …

Prior tumor cell studies have shown that the drugs sorafenib (Nexavar) and regorafenib
(Stivarga) reduce expression of the chaperone GRP78. Sorafenib/regorafenib and the multi …

We determined one mechanism by which the putative phosphoinositide-dependent kinase
(PDK)-1 inhibitor 2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1 H-pyrazol-1-yl] …