We examined the interaction between OSU‐03012 (also called AR‐12) with
phosphodiesterase 5 (PDE5) inhibitors to determine the role of the chaperone glucose …

Abstract Background I'm-Yunity™(PSP) is a mushroom extract derived from deep-layer
cultivated mycelia of the patented Cov-1 strain of Coriolus versicolor (CV), which contains as …

Background An increasing number of reports is challenging the notion that the antitumor
potential of the selective COX-2 inhibitor celecoxib (Celebrex®) is mediated primarily via the …

We have further defined mechanism (s) by which 2-amino-N-{4-[5-(2-phenanthrenyl)-3-
(trifluoromethyl)-1 H-pyrazol-1-yl]-phenyl} acetamide [OSU-03012 (OSU)], a derivative of the …

The present studies examined the toxic interaction between the non-coxib celecoxib
derivative OSU-03012 and phosphodiesterase 5 (PDE5) inhibitors, and also determined the …

Colorectal cancer (CRC) is a serious yet preventable disease. The low acceptance and cost
of colonoscopy as a screening method for CRC make chemoprevention an important option …

Clinical and preclinical studies provide strong evidence that nonsteroidal anti-inflammatory
drugs (NSAIDs) can prevent numerous types of cancers, especially colorectal cancer …

Nonsteroidal anti‐inflammatory drugs (NSAIDs) have long been used for the treatment of
pain and inflammation because of their inhibitory effects on cyclooxygenase (COX). For …

Cumulative evidence shows that eicosanoids such as prostaglandins, leukotrienes,
thromboxanes and hydroxy eicosatetraenoic acids play an important role in associating …

One in eight women in the United States will be diagnosed with invasive breast cancer in
her lifetime. Advances in therapeutic strategies, diagnosis, and improved awareness have …