Beyond COX-inhibition:'side-effects' of ibuprofen on neoplastic development and progression
Ibuprofen is a non-steroidal anti-inflammatory drug of generalized use with over-thecounter
availability. Population-based studies have provided evidence that its long-term use is …
availability. Population-based studies have provided evidence that its long-term use is …
OSU-03012 interacts with lapatinib to kill brain cancer cells
L Booth, N Cruickshanks, T Ridder… - Cancer Biology & …, 2012 - Taylor & Francis
We have further defined mechanism (s) by which the drug OSU-03012 (OSU) kills brain
cancer cells. OSU toxicity was enhanced by the HSP90 inhibitor 17-N-Allylamino-17 …
cancer cells. OSU toxicity was enhanced by the HSP90 inhibitor 17-N-Allylamino-17 …
The metabolism and pharmacokinetics of phospho‐sulindac (OXT‐328) and the effect of difluoromethylornithine
G Xie, T Nie, GG Mackenzie, Y Sun… - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE Phospho‐sulindac (PS; OXT‐328) prevents colon cancer
in mice, especially when combined with difluoromethylornithine (DFMO). Here, we explored …
in mice, especially when combined with difluoromethylornithine (DFMO). Here, we explored …
Cytotoxic effects of celecoxib on Raji lymphoma cells correlate with aggravated endoplasmic reticulum stress but not with inhibition of cyclooxygenase-2
ST Chen, S Thomas, KJ Gaffney, SG Louie… - Leukemia research, 2010 - Elsevier
Inhibition of cyclooxygenase 2 (COX-2) by the selective COX-2 inhibitor celecoxib has been
suggested as potentially useful for B-cell lymphoma therapy. However, additional …
suggested as potentially useful for B-cell lymphoma therapy. However, additional …
Phosphodiesterases in non-neoplastic appearing colonic mucosa from patients with colorectal neoplasia
B Mahmood, MMB Damm, TSR Jensen, MB Backe… - BMC cancer, 2016 - Springer
Background Intracellular signaling through cyclic nucleotides, both cyclic AMP and cyclic
GMP, is altered in colorectal cancer. Accordingly, it is hypothesized that an underlying …
GMP, is altered in colorectal cancer. Accordingly, it is hypothesized that an underlying …
Positional isomers of aspirin are equally potent in inhibiting colon cancer cell growth: Differences in mode of cyclooxygenase inhibition
R Kodela, M Chattopadhyay, S Goswami, ZY Gan… - … of Pharmacology and …, 2013 - ASPET
We compared the differential effects of positional isomers of acetylsalicylic acid (o-ASA, m-
ASA, and p-ASA) on cyclooxygenase (COX) inhibition, gastric prostaglandin E2 (PGE2) …
ASA, and p-ASA) on cyclooxygenase (COX) inhibition, gastric prostaglandin E2 (PGE2) …
[图书][B] Prospects for chemoprevention of colorectal neoplasia: emerging role of anti-inflammatory drugs
AT Chan, E Detering - 2012 - books.google.com
The prevention of colorectal cancer is a subject of increasing medical importance, and there
have been a number of promising recent developments. This book examines in detail …
have been a number of promising recent developments. This book examines in detail …
Decrease in uptake of arachidonic acid by indomethacin in LS174T human colon cancer cells; a novel cyclooxygenase-2-inhibition-independent effect
T Orido, H Fujino, T Kawashima, T Murayama - Archives of biochemistry …, 2010 - Elsevier
Nonsteroidal anti-inflammatory drugs (NSAIDs) have chemopreventive activity and may be
suitable for treatment of colorectal cancer. A popular and potent NSAID, indomethacin, is …
suitable for treatment of colorectal cancer. A popular and potent NSAID, indomethacin, is …
Novel therapeutics: NSAIDs, derivatives, and phosphodiesterases
HN Tinsley, GA Piazza - Current colorectal cancer reports, 2012 - Springer
The chemopreventive efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) for
colorectal cancer has been well documented. However, long-term use of NSAIDs is …
colorectal cancer has been well documented. However, long-term use of NSAIDs is …
Cell proliferation activity unrelated to COX-2 expression in ovarian tumors
The objective of this study was to assess the expression of Cyclooxygenase-2 (COX-2) and
cell proliferation activity (Ki67 expression) in benign, borderline, and malignant serous and …
cell proliferation activity (Ki67 expression) in benign, borderline, and malignant serous and …