Integration of GC–MS and LC–MS for untargeted metabolomics profiling

ÖC Zeki, CC Eylem, T Reçber, S Kır… - Journal of Pharmaceutical …, 2020 - Elsevier
Recently, metabolomics analyses have become increasingly common in the general
scientific community as it is applied in several researches relating to diseases diagnosis …

Environmental metabolomics: an emerging approach to study organism responses to environmental stressors

BP Lankadurai, EG Nagato… - Environmental …, 2013 - cdnsciencepub.com
Metabolomics is the analysis of endogenous and exogenous low molecular mass
metabolites within a cell, tissue, or biofluid of an organism in response to an external …

[PDF][PDF] The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting α-ketoglutarate to 2-hydroxyglutarate

PS Ward, J Patel, DR Wise, O Abdel-Wahab… - Cancer cell, 2010 - cell.com
The somatic mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) observed in gliomas
can lead to the production of 2-hydroxyglutarate (2HG). Here, we report that tumor 2HG is …

Metabolomics: a global biochemical approach to drug response and disease

R Kaddurah-Daouk, BS Kristal… - Annu. Rev. Pharmacol …, 2008 - annualreviews.org
Metabolomics is the study of metabolism at the global level. This rapidly developing new
discipline has important potential implications for pharmacologic science. The concept that …

Standard operating procedures for pre-analytical handling of blood and urine for metabolomic studies and biobanks

P Bernini, I Bertini, C Luchinat, P Nincheri… - Journal of biomolecular …, 2011 - Springer
Abstract 1 H NMR metabolic profiling of urine, serum and plasma has been used to monitor
the impact of the pre-analytical steps on the sample quality and stability in order to propose …

Metabolomics tools for identifying biomarkers for neuropsychiatric diseases

MP Quinones, R Kaddurah-Daouk - Neurobiology of disease, 2009 - Elsevier
The repertoire of biochemicals (or small molecules) present in cells, tissue, and body fluids
is known as the metabolome. Today, clinicians utilize only a very small part of the …

[HTML][HTML] Green systems biology—from single genomes, proteomes and metabolomes to ecosystems research and biotechnology

W Weckwerth - Journal of proteomics, 2011 - Elsevier
Plants have shaped our human life form from the outset. With the emerging recognition of
world population feeding, global climate change and limited energy resources with fossil …

Metabolomic tools used in marine natural product drug discovery

KA Stuart, K Welsh, MC Walker… - Expert Opinion on Drug …, 2020 - Taylor & Francis
Introduction: The marine environment is a very promising resource for natural product
research, with many of these reaching the market as new drugs, especially in the field of …

PANOMICS at the interface of root–soil microbiome and BNI

A Ghatak, P Chaturvedi, S Waldherr, GV Subbarao… - Trends in Plant …, 2023 - cell.com
Nitrification and denitrification are soil biological processes responsible for large nitrogen
losses from agricultural soils and generation of the greenhouse gas (GHG) N 2 O. Increased …

Combined application of NMR-and GC-MS-based metabonomics yields a superior urinary biomarker panel for bipolar disorder

J Chen, Z Liu, S Fan, D Yang, P Zheng, W Shao, Z Qi… - Scientific reports, 2014 - nature.com
Bipolar disorder (BD) is a debilitating mental disorder that cannot be diagnosed by objective
laboratory-based modalities. Our previous studies have independently used nuclear …