Introduction In haematopoietic stem cell transplantation (HSCT), haematopoietic stem cells
(HSCs) from a healthy donor replace the patient's ones. Ex vivo HSC gene therapy (HSC …

Tumors evolve together with the tumor microenvironment (TME) and reshape it towards
immunosuppression. Immunostimulating cytokines can be used to revert this state leading to …

Mobilized peripheral blood is increasingly used instead of bone marrow as a source of
autologous hematopoietic stem/progenitor cells for ex vivo gene therapy. Here, we present …

Despite promising results shown in hematologic tumors, immunotherapies for the treatment
of solid tumors have mostly failed so far. The immunosuppressive tumor microenvironment …

Chimeric antigen receptor (CAR) monocyte and macrophage therapies are promising solid
tumor immunotherapies that can overcome the challenges facing conventional CAR T cell …

Simple Summary The tumor microenvironment comprises numerous different cellular
players that engage transformed cancer cells and may exert pro-vs anti-tumor functions …

Glioblastoma WHO IV (GBM), the most common primary brain tumor in adults, is a
heterogenous malignancy that displays a reprogrammed metabolism with various fuel …

Type I interferons have long been appreciated as a cytokine family that regulates antiviral
immunity. Recently, their role in eliciting antitumor immune responses has gained increasing …

Hypocretin-1 is a multifunctional neuropeptide that has been identified as a potential
antitumor agent for its role in inhibiting tumor growth, including in colon cancer …

Simple Summary In the present review, we reported the main findings describing tumor-
associated microenvironment in patients with IDH mutated and wild-type gliomas. We also …