Purpose: To present a review of most commonly used techniques to analyze dynamic
contrast‐enhanced magnetic resonance imaging (DCE‐MRI), discusses their strengths and …

The blood-brain barrier (BBB) is a vital component of the neurovascular unit (NVU)
containing tight junctional (TJ) proteins and different ion and nutrient transporters which …

The Tofts model (TM) and extended Tofts model (ETM) have become a standard for the
analysis of dynamic contrast‐enhanced MRI. In this study, a mathematical analysis is used …

The blood protein fibrinogen as a ligand for integrin and non-integrin receptors functions as
the molecular nexus of coagulation, inflammation and immunity. Studies in animal models …

Much research has focussed on the development of novel therapeutic agents to target
various central nervous system disorders, however less attention has been given to …

Background: In experimental models of cerebral ischemia, thrombolytic drugs have been
demonstrated to have a number of neurovascular toxic effects including blood brain barrier …

Neuroinflammation mediated by activation of microglia and interruption of the blood-brain
barrier (BBB) is an important factor that contributes to neuron death and infarct area diffusion …

Cerebral stroke is one of the most frequent causes of permanent disability or death in the
western world and a major burden in healthcare system. The major portion is caused by …

Stroke is a major cause of mortality and long-term disability worldwide. The initial changes in
local perfusion and tissue status underlying loss of brain function are increasingly …

Focused ultrasound (FUS) in conjunction with microbubbles has been shown to successfully
open the blood–brain barrier (BBB) in the mouse brain. In this study, we compute the BBB …