Background The conduct of rare disease clinical trials is still hampered by methodological
problems. The number of patients suffering from a rare condition is variable, but may be very …

Background Abnormalities in birth weight and gestational age cause several adverse
maternal and infant out-comes. Our study aims to determine the potential factors that affect …

Background Caesarean section (C-section) in Bangladesh have received great attention as
the number has been amplified during the last two decades. The question arises whether …

ABSTRACT A random effects model for analyzing mixed longitudinal count and ordinal data
is presented where the count response is inflated in two points (k and l) and an (k, l)-Inflated …

The Women's Health Initiative (WHI) Life and Longevity After Cancer (LILAC) study is an
excellent resource for studying the quality of life following breast cancer treatment. At study …

Molenberghs, Verbeke, and Demétrio (2007) and Molenberghs et al.(2010) proposed a
general framework to model hierarchical data subject to within-unit correlation and/or …

Longitudinal data together with recurrent events are commonly encountered in clinical trials.
In many applications, these two processes are highly correlated. When there exist a large …

In many applications, we frequently encounter correlated multiple outcomes measured on
the same subject. Joint modeling of such multiple outcomes can improve efficiency of …

In this paper, we propose joint random effects models for longitudinal mixed overdispersion
binomial and normal responses where the overdispersion binomial response is inflated in …

In this methodological study, we address the joint modeling of longitudinal data on the
frequency and duration migraine attacks collected from patients in a clinical study in which …