Bee venom: an updating review of its bioactive molecules and its health applications

M Carpena, B Nuñez-Estevez, A Soria-Lopez… - Nutrients, 2020 - mdpi.com
Bee venom (BV) is usually associated with pain since, when humans are stung by bees,
local inflammation and even an allergic reaction can be produced. BV has been traditionally …

Computational methods and tools in antimicrobial peptide research

PGA Aronica, LM Reid, N Desai, J Li… - Journal of Chemical …, 2021 - ACS Publications
The evolution of antibiotic-resistant bacteria is an ongoing and troubling development that
has increased the number of diseases and infections that risk going untreated. There is an …

Therapeutic Use of Bee venom and potential applications in veterinary medicine

R Bava, F Castagna, V Musella, C Lupia, E Palma… - Veterinary …, 2023 - mdpi.com
Simple Summary Bee products consist of many substances that have long been known for
their medicinal and health-beneficial properties. Venom is certainly the one that has …

How melittin inserts into cell membrane: conformational changes, inter-peptide cooperation, and disturbance on the membrane

J Hong, X Lu, Z Deng, S Xiao, B Yuan, K Yang - Molecules, 2019 - mdpi.com
Antimicrobial peptides (AMPs), as a key component of the immune defense systems of
organisms, are a promising solution to the serious threat of drug-resistant bacteria to public …

Mechanistic understanding from molecular dynamics in pharmaceutical research 2: lipid membrane in drug design

T Róg, M Girych, A Bunker - Pharmaceuticals, 2021 - mdpi.com
We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …

Strategies for Improving Transdermal Administration: New Approaches to Controlled Drug Release

O Dumitriu Buzia, AM Păduraru, CS Stefan, M Dinu… - Pharmaceutics, 2023 - mdpi.com
In this work, we aim to address several strategies to improve transdermal drug delivery, such
as iontophoresis, sonophoresis, electroporation and micron. We also propose a review of …

Anisaxins, helical antimicrobial peptides from marine parasites, kill resistant bacteria by lipid extraction and membrane disruption

T Rončević, M Gerdol, M Mardirossian, M Maleš… - Acta biomaterialia, 2022 - Elsevier
An infecting and propagating parasite relies on its innate defense system to evade the host's
immune response and to survive challenges from commensal bacteria. More so for the …

Electrochemiluminescence imaging of liposome permeabilization by an antimicrobial peptide: melittin

F Ben Trad, J Delacotte… - … & Biomedical Imaging, 2023 - ACS Publications
The permeabilization of liposomes by melittin, an antimicrobial peptide (AMP), has been
studied by an electrochemiluminescence (ECL) imaging strategy. The methodology …

The membrane effects of melittin on gastric and colorectal cancer

C Soliman, S Eastwood, VK Truong, PA Ramsland… - PLoS …, 2019 - journals.plos.org
The cytotoxic effects of melittin, a bee-venom peptide, have been widely studied towards
cancer cells. Typically, these studies have examined the effect of melittin over extended-time …

Cooperative antimicrobial action of melittin on lipid membranes: A coarse-grained molecular dynamics study

Y Miyazaki, W Shinoda - Biochimica et Biophysica Acta (BBA) …, 2022 - Elsevier
We conducted a series of coarse-grained molecular dynamics (CG-MD) simulations to
investigate the complicated actions of melittin, which is an antimicrobial peptide (AMP) …