[HTML][HTML] A comprehensive review of the current knowledge of chlorfenapyr: synthesis, mode of action, resistance, and environmental toxicology

P Huang, X Yan, B Yu, X He, L Lu, Y Ren - Molecules, 2023 - mdpi.com
Creating new insecticide lead compounds based on the design and modification of natural
products is a novel process, of which chlorfenapyr is a typical successful example …

[HTML][HTML] SDHi fungicides: An example of mitotoxic pesticides targeting the succinate dehydrogenase complex

CD Hospital, A Tête, K Debizet, J Imler… - Environment …, 2023 - Elsevier
Succinate dehydrogenase inhibitors (SDHi) are fungicides used to control the proliferation of
pathogenic fungi in crops. Their mode of action is based on blocking the activity of succinate …

Design, synthesis biological activity, and docking of novel fluopyram derivatives containing guanidine group

P Liang, S Shen, Q Xu, S Wang, S Jin, H Lu… - Bioorganic & Medicinal …, 2021 - Elsevier
Succinate dehydrogenase (SDH), a crucial bridge enzyme between the respiratory electron
transfer chain and tricarboxylic acid (or Krebs) cycle, has been identified as an ideal target …

[HTML][HTML] Insect cell-based models: cell line establishment and application in insecticide screening and toxicology research

X He, L Lu, P Huang, B Yu, L Peng, L Zou, Y Ren - Insects, 2023 - mdpi.com
Simple Summary Insect cell lines have often been employed in pest management, where
they have been used as tools to evaluate the activity and explore the toxic mechanisms of …

[HTML][HTML] Unravelling the polytoxicology of chlorfenapyr on non-target HepG2 cells: The involvement of mitochondria-mediated programmed cell death and DNA …

Y Ren, X He, X Yan, Y Yang, Q Li, T Yao, L Lu, L Peng… - Molecules, 2022 - mdpi.com
Chlorfenapyr (CHL) is a type of insecticide with a wide range of insecticidal activities and
unique targets. The extensive use of pesticides has caused an increase in potential risks to …

Bixafen causes cardiac toxicity in zebrafish (Danio rerio) embryos

M Yuan, W Li, P Xiao - Environmental Science and Pollution Research, 2021 - Springer
Bixafen (BIX) is a succinate dehydrogenase inhibitor (SDHI)-class fungicide that is used to
control crop diseases. However, data on the toxicity of BIX to zebrafish are limited. Here …

[HTML][HTML] Oxidative stress and apoptosis in Asian honey bees (A. cerana) exposed to multiple pesticides in intensive agricultural landscape

D Kumar, D Banerjee, P Chakrabarti, S Sarkar, P Basu - Apidologie, 2022 - Springer
Pesticide usage associated with intensive agriculture is implicated as a major factor for
pollinator decline. Apart from developmental and physiological impairments, pesticide …

Isochamaejasmin induces toxic effects on Helicoverpa zea via DNA damage and mitochondria‐associated apoptosis

Y Ren, Q Li, L Lu, H Jin, K Tao… - Pest Management …, 2021 - Wiley Online Library
BACKGROUND Stellera chamaejasme L. is a poisonous plant with rich resources and is
thus highly valuable in terms of new pesticide development. Isochamaejasmin (ICM), one of …

Neochamaejasmin B extracted from Stellera chamaejasme L. induces apoptosis through caspase‐10‐dependent way in insect neuronal cells

G Gu, M Jiang, H Hu, W Qiao, H Jin… - Archives of Insect …, 2022 - Wiley Online Library
To explore the toxicity mechanisms of neochamaejasmin B (NCB) extracted from Stellera
chamaejasme L., we first evaluated its cytotoxicity in neuronal cells of Helicoverpa zea (AW1 …

[HTML][HTML] Mitochondria-mediated apoptosis and autophagy participate in buprofezin-induced toxic effects in non-target A549 cells

Y Ren, X He, Y Yang, Y Cao, Q Li, L Lu, L Peng, L Zou - Toxics, 2022 - mdpi.com
Buprofezin (BUP) is an insecticide used for control of sucking pests. Its widespread use has
raised concerns about possible adverse effects on the environment, and especially human …