The purpose of this work is to review the published studies on the mechanisms of action and
resistance of 5-fluorouracil. The review is divided into three main sections: mechanisms of …

Over the past decades, promising therapies targeting different signaling pathways have
emerged. Among these pathways, apoptosis has been well investigated and targeted to …

Recent preliminary studies reported the in vitro tumor-promoting effects of long non-coding
RNA urothelial carcinoma associated 1 (UCA1) in colorectal cancer (CRC). However, the in …

Solid tumors with disorganized, insufficient blood supply contain hypoxic cells that are
resistant to radiotherapy and chemotherapy. Drug resistance, an obstacle to curative …

Aim To investigate the anti-proliferative effects of Crocus sativus extract and its major
constituent, crocin, on three colorectal cancer cell lines (HCT-116, SW-480, and HT-29). The …

The platinum compound oxaliplatin has been shown to be an effective chemotherapeutic
agent for the treatment of colorectal cancer. In this study, we investigate the molecular …

Autophagy has become one of the most important mechanisms of chemotherapy resistance
by supporting the survival of tumor cells under metabolic and therapeutic stress. Here, we …

Combinatorial chemo and gene therapy provides a promising way to cure drug-resistant
cancer, since the codelivered functional nucleic acids can regulate drug resistance genes …

Resistance to 5-Fluorouracil chemotherapy is a major cause of therapeutic failure in colon
cancer cure. Development of combined therapies constitutes an effective strategy to inhibit …

Gingerol, a natural product of ginger, has been known to possess anti‐tumorigenic and pro‐
apoptotic activities. However, the mechanisms by which it prevents cancer are not well …