Lung cancer remains a serious public health problem and is the first cause of cancer death
worldwide, and the overall 5-year survival rate for all stages is 14–17% for Non-small-cell …

The development of targeted therapies has revolutionized cancer treatment, offering
improved efficacy with reduced side effects compared with traditional chemotherapy. This …

Abstract Purpose Circular RNAs (circRNAs), a large class of non-coding RNAs with
covalently closed-loop structures, are abundant, stable, conserved, and have tissue and …

The development of genetic engineering in the 1970s marked a new frontier in genome-
editing technology. Gene-editing technologies have provided a plethora of benefits to the life …

Background/Aims: Lung adenocarcinoma, a form of non-small cell lung cancer with high
lethality at an advanced stage, is becoming more common in women, non-or never-smokers …

Circular RNAs (circRNAs) have an important function in human diseases, especially in
cancer. circRNA hsa_circ_0014130 (circPIP5K1A), a particularly abundant circRNA …

The cancer stem cell (CSC) model is based on a myriad of experimental and clinical
observations suggesting that the malignant phenotype is sustained by a subset of cells …

In the eukaryotic transcriptome, the evolutionary conserved circular RNAs naturally occur
from the family of noncoding RNAs. Circular RNAs possess a unique feature to interact with …

Purpose This study evaluated occurrence and potential clinical significance of intratumoral
EGFR mutational heterogeneity in Chinese patients with non-small cell lung cancer …

One of the fundamental discoveries in the field of biology is the ability to modulate the
genome and to monitor the functional outputs derived from genomic alterations. In order to …