For over a century, scientists have strived to understand the mechanisms that govern the
accurate segregation of chromosomes during mitosis. The most intriguing feature of this …

Abstract Nearly 60 years ago, Alan Turing showed theoretically how two chemical species,
termed morphogens, diffusing and reacting with each other can generate spatial patterns …

Abstract Background Kinesin superfamily (KIFs) has a long-reported significant influence on
the initiation, development, and progress of breast cancer. However, the prognostic value of …

Mitotic spindles are self-organizing protein machines that harness teams of multiple force
generators to drive chromosome segregation. Kinesins are key members of these force …

Precise control of the attachment strength between kinetochores and spindle microtubules is
essential to preserve genomic stability. Aurora B kinase has been implicated in regulating …

Microtubules are dynamic polymers of αβ-tubulin that form diverse cellular structures, such
as the mitotic spindle for cell division, the backbone of neurons, and axonemes. To control …

Motor proteins in the kinesin-8 family depolymerize microtubules in a length-dependent
manner that may be crucial for controlling the length of organelles such as the mitotic …

Microtubules are long cylindrical polymers composed of tubulin subunits. In cells,
microtubules play an essential role in architecture and motility. For example, microtubules …

Chromosomal instability (CIN) is a hallmark of tumor cells caused by changes in the
dynamics and control of microtubules that compromise the mitotic spindle. Thus, CIN cells …

During metaphase, forces on kinetochores are exerted by k-fibres, bundles of microtubules
that end at the kinetochore. Interestingly, non-kinetochore microtubules have been observed …