Mitotic spindle assembly is crucial for chromosome segregation and relies on bundles of
microtubules that extend from the poles and overlap in the middle. However, how these …

An increase in centrosome number is commonly observed in cancer cells, but the role
centrosome amplification plays along with how and when it occurs during cancer …

Microtubule (MT) kinesin motor proteins orchestrate various cellular processes (eg mitosis,
motility and organelle transportation) and have been implicated in human carcinogenesis …

Kinesin-8s are dual-activity motor proteins that can move processively on microtubules and
depolymerize microtubule plus-ends, but their mechanism of combining these distinct …

Mitotic spindle positioning specifies the plane of cell division during anaphase. Spindle
orientation and positioning are therefore critical to ensure symmetric division in mitosis and …

What forces drive chromosome segregation remains one of the most challenging questions
in cell division. Even though the duration of anaphase is short, it is of utmost importance for …

Regulation of microtubule (MT) dynamics is essential for proper spindle assembly and
organization. Kinesin-8 family members are plus-end-directed motors that modulate plus …

The mitotic spindle is a macromolecular structure utilized to properly align and segregate
sister chromatids to two daughter cells. During mitosis, the spindle maintains a constant …

Centromeres are scaffolds for the assembly of kinetochores that ensure chromosome
segregation during cell division. How vertebrate centromeres obtain a three-dimensional …

This study aimed to investigate KIF18A expression in hepatocellular carcinoma (HCC) and
to determine the possibility of KIF18A expression being a biomarker in HCC diagnosis or …