Genomic copy number imbalances are being increasingly identified as an important cause
of intellectual disability and behavioral abnormalities. The typical deletion in WAGR …

Most cancer cells show chromosomal instability, a condition where chromosome
missegregation occurs frequently. We found that chromosome oscillation, an iterative …

Molecular motors play critical roles in the formation of mitotic spindles, either through
controlling the stability of individual microtubules, or by crosslinking and sliding microtubule …

Generation of motile force is one of the main functions of the eukaryotic kinetochore during
cell division. In recent years, the KMN network of proteins (Ndc80 complex, Mis12 complex …

Kinesin was discovered in 1985–25 years ago–based on its motility in cytoplasm extruded
from the giant axon of the squid (Allen et al., 1982; Brady et al., 1982; Vale et al., 1985). The …

Microtubules (MTs) are central to the organisation of the eukaryotic intracellular space and
are involved in the control of cell morphology. For these purposes, MT polymerisation …

Aurora B kinase phosphorylates kinetochore proteins during early mitosis, increasing
kinetochore–microtubule (MT) turnover and preventing premature stabilization of …

Cytoplasmic dynein has been implicated in diverse mitotic functions, several involving its
association with kinetochores. Much of the supporting evidence comes from inhibition of …

During mitosis, individual microtubules make attachments to chromosomes via a specialized
protein complex called the kinetochore to faithfully segregate the chromosomes to daughter …

During metaphase, chromosomes are aligned in a lineup at the equatorial plane of the
spindle to ensure synchronous poleward movement of chromatids in anaphase and proper …