Skeletal muscle is a crucial tissue for movement, gestural assistance, metabolic
homeostasis, and thermogenesis. It makes up approximately 40% of the total body weight …

Various diseases can cause skeletal muscle atrophy, usually accompanied by inflammation,
mitochondrial dysfunction, apoptosis, decreased protein synthesis, and enhanced …

Skeletal muscle atrophy is the consequence of protein degradation exceeding protein
synthesis because of disease, aging, and physical inactivity. Patients with skeletal muscle …

Efficacy and selectivity of molecules inducing protein degradation depend on their affinity to
the target protein but also on the type of E3 ubiquitin ligase that is recruited to trigger …

Diabetes mellitus (DM) is a typical chronic disease that can be divided into 2 types,
dependent on insulin deficiency or insulin resistance. Incidences of diabetic complications …

The maintenance of muscle homeostasis is vital for life and health. Skeletal muscle atrophy
not only seriously reduces people's quality of life and increases morbidity and mortality, but …

Lung cancer is a common malignant tumor that occurs in the human body and poses a
serious threat to human health and quality of life. The existing treatment methods mainly …

Protein homeostasis deficiencies underlie various cancers and neurodegenerative
diseases. The ubiquitin-proteasome system (UPS) and autophagy are responsible for most …

As the ubiquitin–proteasome system (UPS) regulates almost every biological process, the
dysregulation or aberrant expression of the UPS components causes many pathological …

Chronic kidney disease (CKD) is a high-risk chronic catabolic disease due to its high
morbidity and mortality. CKD is accompanied by many complications, leading to a poor …