Antimicrobial peptides (AMPs), critical components of the innate immune system, are widely
distributed throughout the animal and plant kingdoms. They can protect against a broad …

The presence of cell and tissue barriers together with the low biomembrane permeability of
various therapeutics often hampers systemic drug distribution; thus, most of the available …

The intrinsic property of cell-penetrating peptides (CPPs) to deliver therapeutic molecules
(nucleic acids, drugs, imaging agents) to cells and tissues in a nontoxic manner has …

Cell membranes with their selective permeability play important functions in the tight control
of molecular exchanges between the cytosol and the extracellular environment as the …

Drug conjugates are conjugates comprising a tumor-homing carrier tethered to a cytotoxic
agent via a linker that are designed to deliver an ultra-toxic payload directly to the target …

Highlights•An unprecedented number of peptide therapeutics have recently been
approved.•Clinical pipeline analysis reveals an emphasis on peptides with enhanced …

Efficient intracellular drug delivery and target specificity are often hampered by the presence
of biological barriers. Thus, compounds that efficiently cross cell membranes are the key to …

A dominant area of antibody research is the extension of the use of this mighty experimental
and therapeutic tool for the specific detection of molecules for diagnostics, visualization, and …

The plasma membrane as a selectively permeable barrier of living cells is essential to cell
survival and function. In many cases, however, the efficient passage of exogenous bioactive …

The penetration of polar or badly soluble compounds through a cell membrane into live cells
requires mechanical support or chemical helpers. Cell‐penetrating peptides (CPPs) are very …