ABSTRACT A milestone in the field of recombinant binding molecules was achieved 30
years ago with the discovery of single-domain antibodies from which antigen-binding …

Transcription poses a threat to genomic stability through the formation of R-loops that can
obstruct progression of replication forks. R-loops are three-stranded nucleic acid structures …

For over 60 years, salicylic acid (SA) has been known as a plant immune signal required for
basal and systemic acquired resistance (SAR). SA activates these immune responses by …

The cobs of sweet corn, also known as vegetable corn, are a nutritionally rich agricultural by-
product. Sweet corncob polysaccharide (SCP-80-I) is a bioactive macromolecule extracted …

Recently, we introduced a chromatin immunoprecipitation (ChIP) technique utilizing the
human DNA Fragmentation Factor (DFF) to digest the DNA prior to immunoprecipitation …

Genome‐wide mapping of transcription factors and chromatin regulators is important to
distinguish their direct from indirect effects on gene transcription or chromatin function. Novel …

Simple Summary UTX/KDM6A is a histone H3K27 demethylase and plays an important role
in mammalian development and human diseases such as urothelial cancer. We identified a …

Background Loss-of-function mutations of the multiple endocrine neoplasia type 1 (MEN1)
gene are causal to the MEN1 tumor syndrome, but they are also commonly found in …

Histone lysine-specific methyltransferase 2 (KMT2A-D) proteins, alternatively called mixed
lineage leukemia (MLL1-4) proteins, mediate positive transcriptional memory. Acting as the …

Background Glioblastoma is the most common and aggressive primary brain tumor with
extremely poor prognosis, highlighting an urgent need for developing novel treatment …