Intractable neuropathic pain is a frequent consequence of nerve injury or disease. When
peripheral nerves are injured, damaged axons undergo Wallerian degeneration. Schwann …

Single-cell RNA sequencing data can unveil the molecular diversity of cell types. Cell type
atlases of the mouse spinal cord have been published in recent years but have not been …

The mammalian spinal cord functions as a community of cell types for sensory processing,
autonomic control, and movement. While animal models have advanced our understanding …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …

The spinal dorsal horn is a major site for the induction and maintenance of mechanical
allodynia, but the circuitry that underlies this clinically important form of pain remains …

Cutaneous somatosensory modalities play pivotal roles in generating a wide range of
sensorimotor behaviors, including protective and corrective reflexes that dynamically adapt …

Allodynia is a state in which pain is elicited by innocuous stimuli. Capsaicin applied to the
skin results in an allodynia that extends to a broad region beyond the application site. This …

Chronic orchialgia can be the result of pathological processes of the scrotal contents or stem
from non-intrascrotal structures. Successful pain management depends on identifying the …

Parvalbumin-expressing interneurons (PVINs) in the spinal dorsal horn are found primarily
in laminae II inner and III. Inhibitory PVINs play an important role in segregating innocuous …

An accelerating basic science literature is providing key insights into the mechanisms by
which spinal neuropeptide Y (NPY) inhibits chronic pain. A key target of pain inhibition is the …