Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

An appropriate balance between self-renewal and differentiation is crucial for stem cell
function during both early development and tissue homeostasis throughout life. Recent …

Stem cells undergo a shift in metabolic substrate utilization during specification and/or
differentiation, a process that has been termed metabolic reprogramming. Here, we report …

SLC1A5, known as ASCT2, is a neutral amino acid transporter belonging to the SLC1 family
and localized in the plasma membrane of several body districts. ASCT2 is an acronym …

Cancer cells require glutamine to adapt to increased biosynthetic activity. The limiting step in
intracellular glutamine catabolism involves its conversion to glutamate by glutaminase (GA) …

All multicellular organisms undergo a decline in tissue and organ function as they age. An
attractive theory is that a loss in stem cell number and/or activity over time causes this …

Skeletal stem cells (SSCs) are postulated to provide a continuous supply of osteoblasts
throughout life. However, under certain conditions, the SSC population can become …

Cancer-related anemia (CRA) is a common sign occurring in more than 30% of cancer
patients at diagnosis before the initiation of antineoplastic therapy. CRA has a relevant …

Human pluripotent stem cells (hPSCs) are uniquely dependent on aerobic glycolysis to
generate ATP. However, the importance of oxidative phosphorylation (OXPHOS) has not …