The complement system is part of innate immunity and is pivotal in protecting the body
against pathogens and maintaining host homeostasis. Activation of the complement system …

Abstract C3 glomerulopathy (C3G) is diagnosed by kidney biopsy, with immunofluorescence
showing isolated or dominant C3 staining, indicating hyperactivity of the alternative …

Iptacopan (FABHALTA®) is an oral complement Factor B inhibitor developed by Novartis
Pharmaceuticals for the treatment of complement-mediated diseases. Acting upstream of …

Uncontrolled complement activation can cause or contribute to glomerular injury in multiple
kidney diseases. While complement activation plays a causal role in atypical hemolytic …

Many kidney diseases are associated with proteinuria. Since proteinuria is independently
associated with kidney function loss, anti-proteinuric medication, often in combination with …

Nephrology is an ever-evolving field of medicine. The importance of such a discipline is
related to the high clinical impact of kidney disease. In fact, abnormalities of kidney function …

The nephrotic syndrome holds significant clinical importance and is characterized by a
substantial protein loss in the urine. Damage to the glomerular basement membrane or …

C3 glomerulopathy (C3G) is a rare disorder marked by deposition of C3 in the glomerulus,
resulting in damage to the glomerular filtration unit and presenting with features of the …

C3 glomerulopathy (C3G) is known for its tendency to recur after kidney transplantation
(KTx), and recurrence has been reported as high as 86% in contemporary cohorts with a …

C3 glomerulopathy is a rare disease caused by fluid phase dysregulation of the alternative
complement pathway. Currently, treatment depends on clinical and histological severity and …