[HTML][HTML] Research on ferroptosis as a therapeutic target for the treatment of neurodegenerative diseases
Y Wang, M Lv, W Zhao - Ageing research reviews, 2023 - Elsevier
Ferroptosis is an iron-and lipid peroxidation (LPO)-mediated programmed cell death type.
Recently, mounting evidence has indicated the involvement of ferroptosis in …
Recently, mounting evidence has indicated the involvement of ferroptosis in …
Discovery of anti-neuroinflammatory agents from 1, 4, 5, 6-tetrahydrobenzo [2, 3] oxepino [4, 5-d] pyrimidin-2-amine derivatives by regulating microglia polarization
Y Yang, ZF Gao, GG Hou, QG Meng, Y Hou - European Journal of …, 2023 - Elsevier
Neuroinflammation mediated by microglia activation leads to various neurodegenerative
and neurological disorders. In order to develop more and better options for this disorders, a …
and neurological disorders. In order to develop more and better options for this disorders, a …
[HTML][HTML] Synthesis of novel benzothiazole derivatives and investigation of their enzyme inhibitory effects against Alzheimer's disease
The use of dual acetylcholinesterase (AChE)–monoamine oxidase B (MAO-B) inhibitors is a
new approach in the treatment of Alzheimer disease (AD). In this work, 14 new …
new approach in the treatment of Alzheimer disease (AD). In this work, 14 new …
Adenophorone, An Unprecedented Sesquiterpene from Eupatorium adenophorum: Structural Elucidation, Bioinspired Total Synthesis and Neuroprotective Activity …
B Yin, X Li, ZX Li, XX Zhu, L Zhang… - Angewandte Chemie …, 2023 - Wiley Online Library
Adenophorone (1), a caged polycyclic sesquiterpene featuring an unprecedented tricyclo
[4.3. 1.05, 9] decane skeleton, was isolated from Eupatorium adenopharum Spreng. The …
[4.3. 1.05, 9] decane skeleton, was isolated from Eupatorium adenopharum Spreng. The …
Discovery of quinazolin-4 (3h)-one derivatives as novel ache inhibitors with anti-inflammatory activities
L Lv, M Maimaitiming, Y Huang, J Yang, S Chen… - European Journal of …, 2023 - Elsevier
Abstract A series of quinazolin-4 (3H)-one derivatives was designed through scaffold-
hopping strategy and synthesized as novel multifunctional anti-AD agents demonstrating …
hopping strategy and synthesized as novel multifunctional anti-AD agents demonstrating …
[HTML][HTML] Neuroprotective Effects of the Lithium Salt of a Novel JNK Inhibitor in an Animal Model of Cerebral Ischemia–Reperfusion
IA Schepetkin, GA Chernysheva, OI Aliev, LN Kirpotina… - Biomedicines, 2022 - mdpi.com
The c-Jun N-terminal kinases (JNKs) regulate many physiological processes, including
inflammatory responses, morphogenesis, cell proliferation, differentiation, survival, and cell …
inflammatory responses, morphogenesis, cell proliferation, differentiation, survival, and cell …
Novel neuroprotective pyromeconic acid derivatives with concurrent anti-Aβ deposition, anti-inflammatory, and anti-oxidation properties for treatment of Alzheimer's …
X Liu, C Yu, Y Yao, H Lai, X Ye, J Xu, J Guo… - European Journal of …, 2023 - Elsevier
We synthesized a series of novel pyromeconic acid-styrene hybrid compounds and
measured their activities in inhibiting Aβ 1-42 self-aggregation and promoting …
measured their activities in inhibiting Aβ 1-42 self-aggregation and promoting …
Synthesis, structural elucidation, in vitro antibacterial activity, DFT calculations, and molecular docking aspects of mixed-ligand complexes of a novel oxime and …
An oxime ligand (HL) was synthesized by the condensation of 4-biphenylhydroxymoyl
chloride with 2-amino-5-bromopyridine. The oxime ligand was reacted with l-phenylalanine …
chloride with 2-amino-5-bromopyridine. The oxime ligand was reacted with l-phenylalanine …
New indole derivatives as multitarget anti-Alzheimer's agents: synthesis, biological evaluation and molecular dynamics
Background: Alzheimer's disease is a neurological disorder that causes brain cells to shrink
and die. Aim: Thirteen novel 'oxathiolanyl','pyrazolyl'and 'pyrimidinyl'indole derivatives were …
and die. Aim: Thirteen novel 'oxathiolanyl','pyrazolyl'and 'pyrimidinyl'indole derivatives were …
In vitro and in vivo biological evaluation of newly synthesized multi-target 20 (R)-panaxadiol derivatives for treating Alzheimer's disease
L Pang, J Li, Z Liu, YS Quan, HH Sui, Y Jia… - European Journal of …, 2022 - Elsevier
An extensive study was performed to discover a series of novel 20 (R)-panaxadiol
derivatives with various substituents at the 3-OH position as nontoxic, brain-permeable, multi …
derivatives with various substituents at the 3-OH position as nontoxic, brain-permeable, multi …