Sleep deprivation severely compromises the ability of human beings to respond to stimuli in
a timely fashion. These deficits have been attributed in large part to failures of vigilant …

Until now, more than 800 distinct G protein-coupled receptors (GPCRs) have been identified
in the human genome. The four subtypes of the adenosine receptor (A 1, A 2A, A 2B and A 3 …

The symptomatology of Restless Legs Syndrome (RLS) includes periodic leg movements
during sleep (PLMS), dysesthesias, and hyperarousal. Alterations in the dopaminergic …

OBJECTIVE: Because of the northern location of Denmark, the length of the day over the
year varies from 7 to 17.5 hours. Experimental and clinical results suggest that the …

Caffeine is the most widely-consumed psychoactive drug in the world, but our understanding
of how caffeine affects our brains is relatively incomplete. Most studies focus on effects of …

Emerging research has demonstrated that genetic variation may impact physiological
responses to caffeine consumption. The purpose of the present review was to systematically …

Purpose: Previous studies suggest that the adenosine receptor antagonist, 7-methylxanthine
(7-MX), retards myopia progression. Our aim was to determine whether 7-MX alters the …

Abstract The adenosine antagonist 7-methylxanthine (7-mx) works against myopia in animal
models. In a clinical trial, 68 myopic children (mean age 11.3 years) received either placebo …

Background: The phosphodiesterase 10 (PDE10) family, identified in 1999, is mainly
expressed in the brain, particularly in the striatum, within the medium spiny neurons, nucleus …

CD73 (ecto-5'-nucleotidase) is a cell surface enzyme that regulates purinergic signalling by
desphosphorylating extracellular AMP to adenosine. 5′-nucleotidases are known to be …