We report that changes of phosphodiesterase-10A (PDE10A) can map widespread
functional imbalance of basal ganglia circuits in a mouse model of DYT1 dystonia …

The present work showed the effects of 8-(-3-chlorostyryl)-caffeine (CSC), an A2A receptors
antagonist and MAO B inhibitor, on behavior and biochemical alterations in 6-OHDA …

Adenosine is a neuromodulator, and rapid increases in adenosine in the brain occur
spontaneously or after mechanical stimulation. However, the regulation of rapid adenosine …

Recent preclinical and clinical data suggest that low dose of caffeine enhances the effects of
common antidepressants. Here we investigated the effects of chronic administration of …

Aims Worrying data indicate that excessive caffeine intake applies to patients suffering from
mental disorders, including depression. It is thus possible to demonstrate the usefulness of …

Although paraquat (PQ) is known to induce pulmonary fibrosis, how it does so is not entirely
clear. To elucidate the mechanisms involved, the profile of gene expression in the lung at …

Trace amines (TAs), endogenous amino acid metabolites that are structurally similar to the
biogenic amines, are endogenous ligands for trace amine-associated receptor 1 (TAAR1), a …

Many drugs targeting dopaminergic system were developed for treating schizophrenia
(antagonists of D2 dopaminergic receptors, eg antipsychotics) or Parkinson'disease …

Abstract D 1-and D 2-types of dopamine receptors are located separately in direct and
indirect pathway striatal projection neurons (dSPNs and iSPNs). In comparison, adenosine …

Depressed patients receiving antidepressant treatment for therapeutic purpose also
consume caffeine in the form of tea or coffee drinks as a part of their daily life. These …