Protein aggregation is a hallmark of neurodegenerative diseases. However, the mechanism
that induces pathogenic aggregation is not well understood. Recently, it has emerged that …

RNA-binding proteins (RBPs) are critical players in RNA expression and metabolism, thus,
the proper regulation of this class of proteins is critical for cellular health. Regulation of RBPs …

Alterations in the components [nucleoporins (Nups)] and function of the nuclear pore
complex (NPC) have been implicated as contributors to the pathogenesis of genetic forms of …

Understanding the pathogenic mechanisms of disease mutations is critical to advancing
treatments. ALS-associated mutations in the gene encoding the microtubule motor KIF5A …

Through mechanisms that remain poorly defined, defects in nucleocytoplasmic transport and
accumulations of specific nuclear-pore-complex-associated proteins have been reported in …

Nucleocytoplasmic transport (NCT) decline occurs with aging and neurodegeneration. Here,
we investigated the NCT pathway in models of amyotrophic lateral sclerosis–fused in …

Disruption of nucleocytoplasmic transport is increasingly implicated in the pathogenesis of
neurodegenerative diseases, including ALS caused by a C9orf72 hexanucleotide repeat …

Exposure of cells to heat or oxidative stress causes misfolding of proteins. To avoid toxic
protein aggregation, cells have evolved nuclear and cytosolic protein quality control (PQC) …

Amyotrophic lateral sclerosis (ALS) is a fatal late-onset neurodegenerative disease that
specifically affects the function and survival of spinal and cortical motor neurons. ALS shares …

Alpha-synuclein SNCA has been implicated in the etiology of Parkinson's disease (PD);
however, the normal function of alpha-synuclein protein and the pathway that mediates its …