Acute brain injuries evoke various response cascades directing the formation of the glial
scar. Here, we report that acute lesions associated with hemorrhagic injuries trigger a re …

Myelin is the lipid-rich structure formed by oligodendrocytes (OLs) that wraps the axons in
multilayered sheaths, assuring protection, efficient saltatory signal conduction and metabolic …

Multiple sclerosis (MS) is a neurological disease characterized by multifocal lesions and
smoldering pathology. Although single-cell analyses provided insights into cytopathology …

Background Therapeutic strategies based on scavenging reactive oxygen species (ROS)
and suppressing inflammatory cascades are effective in improving functional recovery after …

Background Oligodendrocytes are glial cells that support and insulate axons in the central
nervous system through the production of myelin. Oligodendrocytes arise throughout …

Since the beautiful images of Santiago Ramón y Cajal provided a first glimpse into the
immense diversity and complexity of cell types found in the cerebral cortex, neuroscience …

Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a
robust, but poorly understood, neuroinflammatory response that contributes to the long-term …

Although different regions of the brain are dedicated to specific functions, the intra-and inter-
regional heterogeneity of astrocytes and microglia in these regions has not yet been fully …

In the developing and adult CNS, new oligodendrocytes (OLs) are generated from a
population of cells known as oligodendrocyte precursor cells (OPCs). As they begin to …

In the developing central nervous system, oligodendrocyte precursor cells (OPCs)
differentiate into oligodendrocytes, which form myelin around axons. Oligodendrocytes and …