The selective vulnerability of specific neuronal subtypes is a hallmark of neurodegenerative
diseases. In this Review, I summarize our current understanding of the brain regions and …

Glial cells, including astrocytes, oligodendrocytes, and microglia, are the major components
in the central nervous system (CNS). Studies have revealed the heterogeneity of each glial …

The intracellular cholesterol transporter NPC1 functions in late endosomes and lysosomes
to efflux unesterified cholesterol, and its deficiency causes Niemann–Pick disease Type C …

Oligodendrocyte progenitor cells (OPCs) originate in the ventricular zone (VZ) of the brain
and spinal cord, and their primary function is to differentiate into oligodendrocytes (OLs) …

Severe traumatic spinal cord injury (SCI) leads to long-lasting oligodendrocyte death and
extensive demyelination in the lesion area. Oligodendrocyte progenitor cells (OPCs) are the …

Purpose: Spinal cord injury (SCI) is a severely crippling injury. Scavenging reactive oxygen
species (ROS) and suppressing inflammation to ameliorate secondary injury using …

Reducing the loss of oligodendrocytes (OLs) is a major goal for neuroprotection after spinal
cord injury (SCI). Therefore, the OL translatome was determined in Ribotag: Plp1-CreERT2 …

In the mouse embryonic forebrain, developmentally distinct oligodendrocyte progenitor cell
populations and their progeny, oligodendrocytes, emerge from three distinct regions in a …

The immune system of skin develops in stages in mice. However, the developmental
dynamics of immune cells in human skin remains elusive. Here, we perform transcriptome …

Highlights•Microglia are resident macrophages of CNS that are involved in brain
homeostasis.•Oligodendrocytes are myelinating cells of the CNS that metabolically support …