There is a growing interest in glial cells in the central nervous system due to their important
role in maintaining brain homeostasis under physiological conditions and after injury. A …

The abnormal growth of oligodendrocyte precursor cells (OPCs) significantly contributes to
the progression of glioblastoma tumors. Hence, molecules that block OPC growth may be of …

Multiple sclerosis (MS) is a neurological disease characterised by multifocal lesions and
smouldering pathology. While single-cell analyses have provided insights into …

The myelinated white matter tracts of the central nervous system (CNS) are essential for fast
transmission of electrical impulses and are commonly affected in neurodegenerative …

Background Oligodendrocyte lineage cells interact with the vasculature in the gray matter.
Physical and functional interactions between blood vessels and oligodendrocyte precursor …

There is an urgent need for therapies that target the multicellular pathology of central
nervous system (CNS) disease. Modified, nonanticoagulant heparins mimic the heparan …

Remyelination biology and the therapeutic potential of restoring myelin sheaths to prevent
neurodegeneration and disability in multiple sclerosis (MS) has made considerable gains …

Traumatic spinal cord injury (SCI) is a life-threatening and life-altering condition that results
in debilitating sensorimotor and autonomic impairments. Despite significant advances in the …

Adolescent social neglect impairs social performance, but the underlying molecular
mechanisms remain unclear. Here we report that isolation rearing of juvenile mice caused …

In the neocortex, oligodendrocytes produce distinct amounts of myelin in each cortical layer
and along the axons of individual neuron types. Here we present a comprehensive single …