The bone is the third most common site of metastasis for a wide range of solid tumors
including lung, breast, prostate, colorectal, thyroid, gynecologic, and melanoma, with 70% of …

Introduction Spinal metastases (SM) are a frequent complication of cancer and may lead to
pathologic vertebral compression fractures (pVCF) and/or metastatic epidural spinal cord …

PURPOSE Pembrolizumab has previously shown antitumor activity against programmed
death ligand 1 (PD-L1)–positive metastatic castration-resistant prostate cancer (mCRPC) …

Background This study evaluated the incidence of de novo bone metastasis across all
primary cancer sites and their impact on survival by primary cancer site, age, race, and sex …

Bone is one of the most common sites of metastasis from advanced solid tumors. Bone
metastasis is a leading cause of pain and increases the risk of skeletal-related events …

Cancer metastases are the main causes for the high mortality of cancer. The current
treatment modality for bone metastasis of breast cancer is dominantly destructive, which …

Osteoclasts are myeloid lineage-derived bone-resorbing cells of hematopoietic origin. They
differentiate from myeloid precursors through a complex regulation process where the …

Understanding the intricacies of lethal prostate cancer poses specific challenges due to
difficulties in accurate modeling of metastasis in vivo. Here we show that NPK EYFP mice …

Background Poly (ADP-ribose) polymerase-inhibitors (PARPis) showed antitumour activity
in BRCA1/2-mutated cancers, with more heterogeneous outcomes in tumours harbouring …

Patients with solid tumours are at risk of impaired bone health from metastases and cancer
therapy-induced bone loss (CTIBL). We review medical management of bone health in …