Tracking early tuberous sclerosis complex diseased organoid development with quantitative oblique back-illumination microscopy

CE Filan, S Charles, PC Costa… - … , and analysis of …, 2023 - spiedigitallibrary.org
Quantitative oblique back-illumination microscopy (qOBM) is a label-free imaging technique
that enables tomographic phase imaging of thick scattering samples with epi-illumination …

Reflectional quantitative phase-contrast microscopy (RQPCM) with annular epi-illumination

Y Ma, Y Wang, L Ma, J Zheng, M Liu, P Gao - Applied Optics, 2022 - opg.optica.org
Quantitative phase microscopy (QPM) is a label-free microscopic technique that exploits the
phase of a wave passing through a sample; hence, it has been applied to many fields …

Handheld quantitative phase imaging probe for in-vivo brain tumor margin assessment

Z Guang, PC Costa, A Jacobs, C Filan… - Label-free Biomedical …, 2023 - spiedigitallibrary.org
Quantitative phase imaging (QPI) enables label-free optical-path-length measurement of
biological samples with nanometer-scale sensitivity, which offers unparalleled access to …

High-speed multifocus phase imaging in thick tissue

S Xiao, S Zheng, J Mertz - Biomedical Optics Express, 2021 - opg.optica.org
Phase microscopy is widely used to image unstained biological samples. However, most
phase imaging techniques require transmission geometries, making them unsuited for thick …

Quantitative oblique back-illumination microscopy with enhanced nuclear phase contrast using acetic acid

Z Guang, A Jacobs, PC Costa, C Filan… - … Phase Imaging IX, 2023 - spiedigitallibrary.org
Quantitative oblique back-illumination microscopy (qOBM) enables quantitative phase
imaging (QPI) in thick samples using epi-illumination. While qOBM offers unprecedented …

Three-dimensional Quantitative Phase Imaging for the Assessment of Glioblastoma Multiforme Treatment Efficacy in Human Spheroids

C Filan, A Davarzani, D Cappabianca… - Microscopy …, 2024 - opg.optica.org
Spheroids offer a unique opportunity to study personalized disease treatment; however,
monitoring of these spheroids relies on time-consuming, end-point analyses. Here we apply …

Real-time, In-vivo, Volumetric Skin Imaging Using Quantitative Oblique Back-illumination Microscopy

S Bharadwaj, Z Guang, Z Li, PC Costa… - Clinical and …, 2024 - opg.optica.org
Currently, dermatologic diagnosis requires lengthy histopathologic analysis, elongating a
patient's time to diagnosis. We present quantitative oblique back-illumination microscopy …

In-Line Assessment of Immunotherapy Cell Cultures using Quantitative Oblique Back-illumination Microscopy

C Filan, PC Costa, B Wang, B Kanwar… - Microscopy …, 2024 - opg.optica.org
Cell therapy is a promising approach to treat disease; however, monitoring cell cultures
during expansion is a significant challenge that hampers quality and reproducible of the …

Quantitative pathology using deep learning

MJ Fanous - 2022 - ideals.illinois.edu
The subfield of pathology known as 'digital pathology'encompasses the procedures for
image acquisition, organization, distribution, labeling, and computational analysis. Digital …

Tracking cellular and subcellular dynamics with quantitative oblique back-illumination microscopy

CE Filan, S Bharadwaj, PC Costa… - … Phase Imaging X, 2024 - spiedigitallibrary.org
Quantitative oblique back-illumination microscopy (qOBM) is a label-free imaging technique
that enables tomographic phase imaging of thick scattering samples with epi-illumination …